List of Therapeutic Companies in New Hampshire - 6

Celdara Medical gives hope and health to patients by transforming academic innovations into medicines that cure the world’s most challenging diseases. We are a recognized leader with a rich stable of discoveries, developed in concert with premiere research institutions in the US, EU, and beyond. We secure lasting partnerships with inventors and their institutions, and provide the developmental, financial, and business acumen to bridge the gaps between discovery and clinical impact. With robust funding options, operations in greater Boston, Washington DC and New York City, growing affiliates in Seattle and Indianapolis, a wealth of opportunities in our pipeline, and partnerships with industry leaders worldwide, Celdara Medical navigates the path from science to medicine, accelerating innovation to improve human health. Celdara Medical - Transforming innovation into medicine.™

Conformal Medical develops medical devices to prevent stroke in patients with non-valvular atrial fibrillation. The company's proprietary technology will help left atrial appendage closure meet its true potential.

ImmuNext is developing immune-based therapeutics to treat patients with immune-related disorders, including autoimmunity, cancer, transplantation rejection, and infectious disease. We are targeting critical immunomodulatory molecules that either promote or suppress immune responses to restore immune homeostasis and cure disease. Using antibody-based therapeutics, a spectrum of newly identified molecules are being targeted to achieve disease remission. Our core competencies are discovery, target biology and pre-clinical drug development. ImmuNext assets: * Immunometabolic Checkpoint Target.Partnered with Eli Lilly in March 2019, therapies targeting a novel transporter target are shown to regulate immune cell metabolism. This opens novel opportunity for treatment of indications with currently limited therapeutic avenues. * Anti-VISTA, a negative checkpoint regulator antagonist for the treatment of cancer, is in the clinic. Partnered with Johnson and Johnson subsidiary, Janssen Biotech, in September, 2012. * VISTA agonists for the treatment of autoimmune disease. Partnered with Hoffman-La Roche in December, 2016, ImmuNext is developing antibodies to VISTA to suppress immune response in multiple inflammatory diseases. The impact of these antibodies is due to the direct suppression of immune cells leading to immune suppression and long term tolerance. * Anti-CD40L antagonists, re-engineered for safety and efficacy. Anti-CD40L was partnered with Sanofi in January, 2017. CD40L (CD154) is a highly validated, superlative therapeutic target in autoimmunity and graft rejection. Dr. Noelle, who discovered CD40L, has re-engineered antagonist antibodies to avoid thromboembolic concerns while maintaining efficacy.

We are a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of our innovative therapy, Tumor Treating Fields. Our commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma and in the U.S. for the treatment of adult patients with malignant pleural mesothelioma. We have ongoing or completed clinical trials investigating Tumor Treating Fields in brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer, liver cancer and gastric cancer. Headquartered in Switzerland, Novocure has U.S. operations in Portsmouth, New Hampshire and Chesterbrook, Pennsylvania. Additionally, Novocure has offices in Canada, Germany, Japan, Poland and Israel.

Vapotherm, Inc. is the inventor of high flow nasal cannula, and its advanced form: Vapotherm high velocity therapy. Delivering high velocity therapy, the Precision Flow® system offers clinicians a reliable tool for multiple patient populations. For respiratory distress patients presenting in the ED and ICU, high velocity therapy can provide not just oxygenation, but also Mask-Free respiratory support with the comfort of heated humidified high flow. Vapotherm, Inc. is a publicly traded company and its common stock trades on the OTCQX tier of the OTC Markets under the symbol "VAPO".

Medical Devices & Diagnostics