List of Therapeutic Companies in Japan - 84

aceRNA Technologies Co., Ltd. is a biotech startup established in 2018 based on RNA design technology developed in synthetic RNA biology research by Prof. Hirohide Saito at Kyoto University. We are developing "smart gene therapy” (mRNA-based and virus-base) that enables control of therapeutic transgene expression in cell-type and -state specific manner. By that, we are committed to develop new therapeutic approach, such as in vivo cell programming.

Aculys - Beyond the development and commercialization of new medicines, Aculys is committed to the patient experience including the awareness, screening, diagnosis, treatment of disease and the resolution of surrounding social issues for patients and their families confronted with neurological and psychiatric disease. The company looks to form comprehensive solutions through cross-sectional partnerships using new technologies to enhance the patient experience.

Alivexis, Inc. (formerly Modulus Discovery, Inc) is a technology-driven drug discovery enterprise with operational foundations in both Japan and the US. By merging state-of-the-art drug discovery platforms with profound knowledge of disease biology and a dynamic global business approach, we are propelling forward our distinct portfolio of small molecule drugs along with a variety of research and development collaborations.

Alpha Fusion Inc. is a clinical-stage startup committed to transforming cancer treatment through the design and development of powerful and precise radiopharmaceuticals. Our radiopharmaceuticals utilize Astatine-211 (211At), alpha-emitting particles that are both effective against cancer and safe for patients. This innovation will significantly impact cancer patients who currently have limited treatment options.

AnGes was founded In December 1999, with the aim of developing hepatocyte growth factor (HGF) gene therapy drugs which can help regenerate blood vessels. Originating from the word angiogenesis meaning the formation of new blood vessels in English, our corporate name AnGes encapsulates our desire to be an angel (ange in French) offering new drugs for patients with hard-to-treat and rare diseases. Both our founder and our employees are still motivated by this desire.

A-SEEDS, an innovative biotech company sprouted from Shinshu University, is dedicated to pioneering advanced treatments for life-threatening cancers. Harnessing the potential of non-viral genetic engineering, our cutting-edge immune cell therapy opens up new horizons of hope for patients seeking effective and transformative solutions.

ASKA Pharmaceutical Co., Ltd. is a leading company in the field of Thyroid disease by through supplying a variety of medicines. Furthermore, we utilize our hormonal technology, aim to contribute all patients for obstetrics and gynecology area.

Axcelead Drug Discovery Partners, Inc. will combine scientific excellence, world-class IP protection and state-of-the art GLP accredited facilities and capabilities to deliver integrated end-to-end early discovery.

The Biken Group is a Specialty Bio-Pharmaceutical Organization that contributes to public health through developing, manufacturing and supplying many of Japan's first vaccines, and also providing laboratory diagnostic services.

Research and development of biopharmaceuticals and bioproducts

Braizon Therapeutics, Inc. is working to solve the blood brain barrier problem for oligonucleotide therapeutics, removing the need for spinal cord injections to treat neurological disorders. Our Brain Access platform utilizes novel IP combining polymer nanoparticles with proven targeting methods for targeting therapies to the brain to create IV formulations for our partners. This platform is under development for expansion into small molecule, peptide, and antibody drug delivery into the brain. HQ'd in Tokyo, Braizon has US operations in Cambridge, MA. enabling our experienced team to offer partnering worldwide for biotech and Pharma with a strategic focus on neurology.

A public biopharmaceutical company focused on developing novel cancer immunotherapies.

Celaid Therapeutics is a Japan-based biotechnology company, which has developed a platform technology to efficiently expand hematopoietic stem cells ex vivo without choosing its origins, including bone marrow, cord blood, or peripheral blood. By using the novel technology, we are developing a cell therapy product that brings HSC transplantation to the next level and helps patients with blood disorders. Our technology has many potential applications including gene/cell therapy that utilize gene editing on HSC. Our mission is to improve QOL of patients, their families, and HSC donors all over the world.

Cellusion is committed to pursuing a patient-centric approach at our cutting-edge research and development (R&D) for diseases where regenerative medicine technologies can create a unique value proposition. We expand the possibilities of people around the world both physically and mentally.

Chiome Bioscience Inc. designs, develops, and sells monoclonal antibody products for medicine, diagnosis, testing, and life sciences. Chiome Bioscience is a clinical stage biotechnology company. Chiome's focus is on discovery and development of antibody-based therapeutics.

Chordia Therapeutics is a clinical-stage biotech company engaged in the research and development of novel therapies for cancers with high unmet medical needs. The Company was spun out from Takeda Pharmaceutical in November 2017.

Chugai’s strength in R&D and antibody technologies continues on in global efforts for products and services for the benefit of patients. Chugai Pharma USA, Inc. (CPUSA), located in Berkeley Heights, NJ, is a wholly owned subsidiary of Chugai Pharmaceutical Co., Ltd. (Chugai). CPUSA supports the planning and execution of global and U.S. clinical programs for Chugai-originated, innovative new drug candidates. Chugai is one of Japan’s leading research-based pharmaceutical companies with strengths in biotechnology products. Chugai, based in Tokyo, specializes in prescription pharmaceuticals and is listed on the 1st section of the Tokyo Stock Exchange. As an important member of the Roche Group, Chugai is actively involved in R&D activities in Japan and abroad. Specifically, Chugai is working to develop innovative products which may satisfy the unmet medical needs in Chugai’s strategic fields of oncology, bone and joint diseases, and renal diseases as well as other therapeutic areas with serious unmet needs. Chugai develops its products independently from Roche until early Proof-of-Concept (PoC) for worldwide market, including U.S. For late stage clinical development and marketing outside of Japan, South Korea, and Taiwan, Chugai seeks for partnership with Roche, which has the first refusal rights to develop/sell Chugai products, or other third parties.

Bio Information is energy! COGNANO, Inc. is a venture to aim for computer-supported drug discovery. The big VHH data obtained from our own alpacas will lead us to a new drug discovery platform. Our goal is to optimize drug designing/development.

Delta-Fly Pharma - We focus not only on cancer itself but on the whole conditions of cancer patients, and aim to deliver medicines that are recommendable for cancer patients and their families. We develop medicines with an original concept called Module Drug Development. Module Drug Development is the assembly of various active ingredients into novel anticancer agents. With this approach and application of drug delivery technologies and knowledge about dosage and administration, drugs with a good balance of safety and efficacy can be developed in a short period of tim

Dioseve Inc. Our revolutionary technology, DIO (Directly Induced Oocyte), is capable of producing an extremely large yield of fertilizable egg cells at a minimal cost.

EA Pharma Co., Ltd. is a pharmaceutical company that promotes drug discovery and clinical development targeting gastrointestinal diseases, particularly Inflammatory Bowel Disease (IBD). The company is focused on creating new innovation through the combined knowledge of its parent companies, Eisai Co., Ltd. and Ajinomoto Co., Inc.

Eisai’s Corporate Concept is “to give first thought to patients and people in the daily living domain, and to increase the benefits that health care provides.” Under this Concept (also known as human health care (hhc) Concept), we aim to effectively achieve social good in the form of relieving anxiety over health and reducing health disparities. With a global network of R&D facilities, manufacturing sites and marketing subsidiaries, we strive to create and deliver innovative products to target diseases with high unmet medical needs, with a particular focus in our strategic areas of Neurology and Oncology. In addition, we demonstrate our commitment to the elimination of neglected tropical diseases (NTDs), which is a target (3.3) of the United Nations Sustainable Development Goals (SDGs), with working on various activities together with global partners.

Epsilon Molecular Engineering (EME) Inc. is an evolutionary molecular engineering based biopharmaceutical drug discovery company. EME was established in 2016 as a venture company from Saitama University in Japan, and has proprietary technologies, unique cDNA display libraries of the heavy chain single domain antibodies (VHH) and cyclic peptides with large diversity (10^13-14), and high-throughput screening methods using next-generation sequence, FACS and Machine learning (Bioinformatics). EME is, currently, conducting several joint research projects, including COVID-19, and 17 ongoing inhouse projects in the arias of cancer, inflammation, and Alzheimer’s disease, etc.

Gene Therapy Research Institution Co., Ltd. is headquartered in Japan. Based on extensive research, the company is committed to providing safe and effective gene therapies for refractory diseases for which effective therapies have not yet been established. Focusing on Parkinson's disease, amyotrophic lateral sclerosis (ALS) and Alzheimer's disease, the company strives to find safer viral vectors and more effective genetic technologies to bring new treatment options to patients.

GlyTech is a science-driven biotechnology company focusing on bringing glycans, which have been called the third chain of life, into practical therapeutic use. Our unparalleled platform technologies of human-type glycan production and glycosylation allow access to highly pure and structurally controlled glycans for drug modification. Our ability to precisely attach desired glycans to a broad range of drug types allows us to support our partners in a wide variety of drug development areas from basic research to manufacturing. A high level of control enables glycosylation patterns (structure, number, position) to be optimized to exploit potential benefits which include increased biological activity, prolonged half-life, and enhanced solubility. Our methods can help our partners　advance discovery targets toward the clinic and develop new biotherapeutics more efficiently. We’ve also overcome one of the greatest barriers to the use of glycans in medicines: limited production capabilities. Our unique platforms allow us to produce both single glycan structures and uniformly glycosylated compounds on a practical and cost-effective scale from the research laboratory to commercialization. We are committed to helping our partners expand their glycoscience research fields, drug development options, and biotherapeutic analysis capabilities. We believe that technology, partnership, and passion are the 3 key success factors in the healthcare industry. With strong experience and an eagerness to tackle new challenges, we are ready to help our partners explore the possibilities of applied glycoscience. We invite you to get our updates by following us on Twitter or here on LinkedIn, or contact us through our homepage: https://www.glytech-inc.com/contact-us/

弊社は、バイオ革命によって急速に発展し始めている再生医療分野において、体性幹細胞再生医薬品/iPSC再生医薬品の研究開発を行っているバイオベンチャーです。2015年6月には東証マザーズに上場。再生・細胞医薬品の開発・製造を世界で先駆けて取り組み、病で苦しむ患者さんに治療法を提供し希望を届けることを目標としています。 Our company is a bio venture which is doing R & D of somatic stem cell regenerating medicine / iPSC regenerating medicine in the regenerative medicine field which is rapidly developing by the bio-revolution. We were listed on TSE Mothers in June 2015. Our long-term object is to deliver hope to patients suffering from illness by providing treatment methods by pioneering the development and manufacture of regeneration and cellular medicines worldwide.

iHeart Japan​ is an venture company developing regenerative medicine products.

With twin platform technologies, Interprotein provides highly active modulators for protein-protein interaction (PPI) targets. Our proprietary technology (INTENDD®) is built upon a different conceptual foundation from MD-based docking simulation methods, generating highly active compounds with unique scaffolds. On the other hand, our newly constructed libraries of helix-loop-helix peptide achieved a near 100% success rate in identifying strong binders with KD values in low nanomolar range. INTENDD® With INTENDD®, we aim to develop and provide an in silico drug design platform specialized for producing small molecule PPI modulators, and extend this technology to establish an AI-based drug discovery program. Helix-loop-helix peptide Alternatively, we have developed extremely diverse libraries of helix-loop-helix peptides for phage-display screening. Phage-displayed random peptide screening enables us to achieve a near 100% success rate in identifying active peptides with high affinity and high specificity to PPI targets. In addition, we can easily modulate pharmacokinetic profiles via multiple approaches. Our promise Through collaborative R&D efforts, we will fully exploit our twin technologies for small molecules and peptides to identify highly active modulators against previously intractable PPI interfaces. We commit to turning current biologics (antibodies and soluble receptors)-based PPI inhibitions into more patient-friendly therapies with small molecule and/or peptide PPI modulators to change patients' lives.

Japan BCG Laboratory was established in 1952 and has produced high-quality BCG (Bacillus Calmette Guérin) vaccine ever since. Japan BCG Laboratory is the sole supplier of this vaccine in Japan. Working with UNICEF, WHO and the Pan American Health Organization (PAHO), Japan BCG Laboratory has distributed its BCG vaccine in more than 50 countries worldwide and has become a respected and longstanding supplier of high-quality products. Japan BCG Laboratory has supplied more than 2.25 billion doses of BCG vaccine for more than 50 years.

Japan Blood Products Organization is a medical device company that is involved in the collection and supply of blood for use in transfusions. They are also engaged in research and development of blood products.

JCR Pharmaceutical is a global specialty pharmaceuticals company that is expanding possibilities for people with rare and genetic diseases worldwide. Our core values – reliability, confidence, and belief – mean that the work we do benefits all our stakeholders, including employees, partners, and patients. We continue to build upon our 49-year legacy in Japan while expanding our global footprint with trials in the US, Europe, and Latin America. We improve patients' lives by applying our scientific expertise and unique technologies to research, develop, and deliver next-generation therapies. We are leaders in developing therapies for rare conditions, including lysosomal storage disorders (LSDs). We are building on the development work we've done in Japan to expand our LSD pipeline: Our first-in-class proprietary technology, J-Brain Cargo®, enables us to develop therapies that cross the blood-brain barrier and penetrate the central nervous system (CNS). The CNS complications of diseases are often severe, resulting in developmental delays, an impact on cognition and, above all, poor prognosis, which affect patients' independence as well as the quality of life of patients and their caregivers. With J-Brain Cargo®, we seek to address the unresolved clinical challenges of LSDs and CNS-related disorders, including neurodegeneration, neuro-oncology, and neuro-inflammation conditions, by delivering the therapy to both the body and the brain. We will continuously try to create value by our unique J-Brain Cargo® technology platform toward our corporate philosophy: “contributing towards people’s healthcare through pharmaceutical products.” In addition to the in-house research activities, we think collaborative research and development work with other companies are also important. The value of our technology platform will be increased by integrating ours with other technologies and by implementing J-Brain Cargo® within other companies’ products.

KAICO is a Japanese biotechnology start-up from Kyushu University, a national university in Japan. We focus on developing and producing recombinant proteins with the core technology, the silkworm-baculovirus expression system. Silkworms are unique insects that can create recombinant proteins within its body. With the silkworm-baculovirus expression system, KAICO uses silkworms as a bioreactor to express diverse recombinant proteins that are hard to extract using other systems, for example, microbes and cells.   Regarding production, distinctive characteristics of the silkworm-baculovirus expression systems are scalability and speediness. It takes less than a week to express target proteins within the body of silkworms. To scale up its production, we increase the number of silkworms. Unlike other expression systems, we do not require bio tanks for scale-up. This makes a speedy transition possible from the research and development phase to mass production.   KAICO’s development programs currently include oral vaccines that are not only for human use but also for animals. An oral vaccine can raise the antibody titer by eating instead of injection. Proteins are decomposed into amino acids when ingested orally. However, KAICO found that even when administered orally, the antibody titer of some proteins expressed in silkworms can be increased.   Through the spread of oral vaccines, we aim to contribute to global public health for human beings and improve the productivity of livestock farmers.   As for human use, compared to injectable vaccines, it has significant merits as follows: 1. No need for syringes and needles. 2. No need for medical personnel for inoculation. 3. No need for cold-chain transportation and storage. By bringing in oral vaccines, KAICO will change the world with silkworms.

Kidswell Bio Corporation (KWB), formerly known as Gene Techno Science, has been growing by leveraging our expertise in Biosimilar field in Japan. By 2024, four BS products were brought to market by our partner pharmaceutical companies as outcomes of co-developments between the companies and KWB. Besides, KWB has engaged in research and development for regenerative medicine with stem cells from human exfoliated deciduous teeth (SHED) since 2019, which targeted pediatric diseases, orphan disease and intractable disease with the aim of achieving comprehensive healthcare solutions for patients suffering from these diseases as well as for their families and caregivers. On the 1st of April 2024, the regenerative medicine business became independent as S-Quatre Corporation (SQ). KWB and SQ lead biosimilar business and regenerative medicine business　respectively, and grow together as two pillars of Kidswell Bio group. キッズウェル・バイオ株式会社(旧株式会社ジーンテクノサイエンス)はバイオシミラー医薬品事業により成長してきた。パートナー製薬企業との共同開発の結果、2024年までに4つのバイオシミラー製品を日本にて上市させている。一方で、2019年からは、乳歯由来歯髄幹細胞を用いた再生医療の研究開発に着手し、希少疾患、難病に加えて、小児疾患を重点的なターゲットと定め、患者様、及びそのご家族や介護者の方を含めた包括的なケアを目指した研究開発を行なってきた。KWBは2024年4月1日にこの再生医療事業を専門に行なう子会社である株式会社S-Quatreを設立し、現在はキッズウェル・バイオグループとしてバイオシミラーと再生医療の両事業を展開している。

KinoPharma - Developing safe topical treatment for cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV) infection of the cervix that could potentially lead to cervical cancer.

Kissei Pharmaceutical - Approaching R&D with Passion and Creativity “Pharmaceutical company cannot exist without R&D.” These words have been passed down at Kissei ever since the company was founded. They show that R&D is an essential and central part of our work, The phrase also expresses the passion of each and every Kissei Pharmaceutical - Kissei employee for the development of new innovative drugs, in the hope that those drugs will help as many people as possible recover as quickly as possible from disease and live lives full of laughter and joy. We aim to develop and supply innovative pharmaceutical products that contribute to the improvement of medicine and the health of people around the world by aggressive incorporation of leading-edge technology and collaborations with our foreign and domestic partners.

KM Biologics' history of vaccine production started with the smallpox vaccine over a half century ago. Since then, we have produced many vaccines including those for typhoid and typhus, and have contributed to the eradication of infectious diseases in Japan. In recent years, through collaborating with companies and universities in Japan and overseas, we have been working on the development of new vaccines such as cell culture-derived influenza vaccines and DPT-based combined vaccines.

KOTAI Biotechnologies, Inc. (KOTAI, Osaka, Japan) is a spinout from Osaka University's world leading research center, Immunology Frontier Research Center launched in 2016. Our unique and sophisticated bioinformatics based on deep structure understandings has enabled us to analyze high throughput sequencing data of the immune systems such as Immune repertoire (BCR, TCR, antibodies, etc) and RNA-seq data. KOTAI is working on discoveries of new biomarkers and therapeutic compounds through the repertoire analysis.

Kubota Pharmaceutical Holdings and its subsidiary Kubota　Vision Inc. are committed to translating innovation into a diverse portfolio of drugs and devices to preserve and restore vision for millions of people worldwide.

Kyorin group is working to realize it corporate philosophy “Kyorin continues to fulfill its mission of cherishing life and benefiting society by contribution to better health.” This content provides the history of KYORIN Group.

Logomix is a synthetic biology company, reshaping the landscape of human genome engineering. Its Geno-Writing™ platform enables precise engineering of Mb-scale genomic sequences within human cells, and thus facilitates the development of super-functionalized cells for the fields of cell therapy, regenerative medicine and any future cell-based therapies.

We are a pre-clinical stage biotechnology company focused on developing functional mitochondria as therapeutic agents, an emerging platform to treat damaged tissues and organs.

Luxna Biotech is a preclinical antisense drug development company based on proprietary modified nucleic acids, unique bridged structure (AmNA, scpBNA, GuNA) and modified DNA (5'-CP) can eliminate phosphorothioated in antisense and siRNA. Currently, better modifications are being discovered that are suitable for applications in neurological diseases that minimize neurotoxicity while maintaining knockdown efficacy in vivo by Gapmer. Based on these findings we developed excellent antisense (ASO) drug discovery platform called “LuxiAPTM” enable to wide therapeutic index for CNS ASO drug. We have several pharmaceutical collaborations and original ASO pipeline including ALS, Spinal cord injury and Hearing loss. We are looking for the partners not only for platform collaboration with pharmaceuticals and biotech but early-stage co-development alliance with our original pipeline.

Metagen Therapeutics, Inc. is a drug discovery and development company that leverages the power of gut microbiome design cultivated in Metabologenomics, Inc. We are eager for partnerships in pharmaceutical, healthcare, functional food, and academia that envisions creating future businesses with one of the best microbiome scientist teams. For inquiries, please contact contact@metagentx.com

Revolutionizing the Way We Treat Heart Failure Heart failure kills more people globally than any other ailments, yet there is no ultimate treatment for the condition. Our goal is to develop and commercialize an effective and reasonably-priced therapy for heart failure using a specific fibroblast cells we call “VCF”, that we obtain from the patient’s own heart. Our approach to heart failure therapy is quite different from other technologies in a sense that we do not want to replace what is “broken”, but rather we want to repair the damage by enhancing the cells’ own ability to heal.

Our founding discoveries came from the labs of Prof. Takagi and Prof Suga (the 2023 winner of the Wolf Prize in Chemistry), both of whom are deeply involved in our R&D to this day. Their innovations enable a novel class of biologics, called “Neobiologics,” that break existing boundaries in biological drug development and will ultimately better, more cost-effective treatments for patients. Internally and with our partners, we are advancing a robust portfolio of products: 1. cMet agonist to HGF (hepatocyte growth factor) to tackle NASH (non-alcoholic steatohepatitis)/fibrosis; currently in IND enabling studies. 2. TrkB agonist of BDNF (brain-derived neurotrophic factor) to tackle neurodegenerative diseases like Alzheimer's Disease and Parkinson’s Disease; currently in vivo studies. 3. Immuno-oncology bi-specific with T-cell engaging activity and a tumor antigen-specific binder; currently in vitro R&D. 4. Undisclosed assets in various stages. This pipeline builds off our core RaPID System and LassoGraft Technology® (LGT) platforms. The RaPID System selects highly active cyclic peptides that tightly bind to drug-target proteins from our diverse library. These peptides are then genetically grafted onto scaffold proteins using LGT to create Neobiologics. Neobiologics break multiple current boundaries for biologics, such as access across the blood-brain barrier, 3D topological design control, multifunctionality (bi-specific, tri-specific, etc.), wide applicability from AAV capsid modulation to antibodies to therapeutic proteins and superior development speeds that drop development costs significantly. Selected publications 1. Mihara, E et al. Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins. Nature Communications (2021)2:1543 2. Sakai, K et al. Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions. Nature Biomedical Engineering 7, 164-176 (2023)

Mochida Pharmaceutical - By aiming to become a comprehensive healthcare company, Mochida Pharmaceutical has made significant contributions in the field of medical care through its pharmaceuticals, healthcare products, and medical equipment businesses. Several years back, to improve the profitability, competitiveness value of all its divisions, Mochida Pharmaceutical split off the Medical Electronics and Equipment Division in 2003, the Healthcare Division in 2004 and the Pharmaceutical Manufacturing Division in 2005. Currently, the Group consists of Mochida Pharmaceutical and five consolidated subsidiaries. We at the Mochida Pharmaceutical Group remain committed as ever to contributing to peoples' health and well-being.

Momotaro-Gene is a biotech start-up company from Okayama University whose main technology lies in tumour suppressor gene. They are focused on the development of a next-generation cancer drug.

NBHL is committed to discovering First-In-Class medicines for the unmet medical needs with the sophisticated drug discovery platforms ( Monoclonal Antibody for GPCR and Small compounds ). We are looking for the pharmaceutical partners to develop the following projects. We are available for the project-based Drug discovery alliance, using our drug discovery platforms powered by PerkinElmer, and Biotech companies.

Nichi-Iko Pharmaceutical is a pharmaceutical company that specializes in healthcare products and medicines.

Nippon Shinyaku Co., Ltd. is a company that has always devoted serious efforts to make people's lives better. All these efforts have been made based on their strong belief that they should build a healthier future. The company is involved in the manufacture and sale of pharmaceuticals and foodstuffs, and its functional food products find application in various industries such as meat processing, fish processing, dairy product, prepared food, confectionery and bakery, and beverage. Nippon Shinyaku also has research laboratories and a botanical research institute, as well as production and logistics facilities. The company is committed to ESG management and provides information to shareholders and investors through its IR activities. Nippon Shinyaku Co., Ltd. is headquartered in Japan and has branch offices and group companies in various locations.

Nobelpharma - “Contribute to Society by Providing Critical but Neglected Pharmaceuticals and Medical Devices” This has remained Nobelpharma’s company mission since we were founded in 2003. “Critical but neglected pharmaceuticals and medical devices” refers to the drugs and medical devices that are not being actively developed by existing pharmaceutical companies because there are only a few patients that require them and thus less viable as a business. At the time of our founding, there were new pharmaceutical candidates (curative drugs) which were already available or under development overseas with confirmed efficacy. However, the patients in Japan were unable to use them. We wanted to resolve this situation (so-called drug lag) ourselves, and deliver these drugs to patients as soon as possible. Nobelpharma was born with such strong will, taking the initiative in responding the issue of unapproved and off-label drugs with high medical needs.

Development of novel cancer immunotherapies mainly using CAR T cells

Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally. In addition to several products being commercialized in Japan, we are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies. This pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across neurology, GI and immunology, metabolic disorders and rare diseases, and leverages the power of our unique and industry leading GPCR-targeted structure-based drug discovery "NxWave" platform to provide a sustainable source of best- or first-in-class candidates. Nxera employs over 350 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and is listed on the Tokyo Stock Exchange (ticker: 4565).

At Ohara, we are aiming to provide not only treatment options for patients, but also aiming to identify and develop innovative tools to improve the quality of diagnosis, prevention and after care in an effort to become a Total Healthcare Solution company for patients.

Oncolys BioPharma Inc. is a Tokyo-based bioventure established in Japan in March 2004. Its mission is to contribute to the advancement of medical science in the world through bringing innovation to the existing treatments for cancer and serious infectious diseases, using its virology-based new drug discovery technologies. The company operates in two business segments. Pharmaceutical Business segment is engaged in the research, development, manufacture and marketing of novel drugs. Its major pipeline Telomelysin (OBP-301), an oncolytic adenovirus immunotherapy is in clinical development targeting various types of solid tumors including melanoma , HCC and esophageal cancer. Along with Telomelysin, an anti-HIV drug OBP-601 (Censavudine) and a novel HDAC inhibitor OBP-801 are also under development in the United States. Diagnostics Business segment is engaged in the research, development, manufacture and marketing of CTC (Circulating Tumor Cell) detection adenovirus TelomeScan, as well as the provision of inspection services. Oncolys was listed on the Tokyo Stock Exchange Mothers Market in December 2014 and has a clinical laboratory center in Kobe, Japan and a subsidiary in New Jersey, USA.

OncoTherapy Science, Inc. provides pharmaceutical companies with yielded drug candidates by using outcomes obtained from joint research with universities and companies. These outcomes include oncogene information isolated by comprehensive analysis of genes specifically expressed in cancer cells and functional analysis information of proteins produced by oncogenes and other gene products. We have also been performing research and development business regarding medications.

We are driving the evolution of next-generation CAR-T cell therapy with precision-engineered CAR constructs. Our CAR discovery engine focuses on optimizing the binding domain of CAR to enhance immune cell function, delivering robust therapeutic efficacy. Optieum is pushing the boundaries of solid tumor treatment powered by next-generation CAR constructs.

This company is a spinout from Takeda Pharmaceuticals and Kyoto University, focusing on the development of induced pluripotent stem cell (iPSC) technology-based regenerative medicine.

PeptiDream Inc. (Tokyo Stock Exchange Prime Market 4587) is leading the translation of macrocyclic peptides into a whole new class of innovative medicines to address unmet medical needs and improve the quality of life of patients worldwide. Founded in 2006, PeptiDream employs its proprietary Peptide Discovery Platform System (PDPS) technology, a state-of-the-art highly versatile discovery platform which enables the production of highly diverse (trillions) non-standard peptide libraries with high efficiency, for the identification of highly potent and selective macrocyclic peptide candidates, which then can be developed into peptide-based, small molecule-based, peptide-drug conjugate (PDC), and multi-functional peptide conjugates (MPC)-based therapeutics and diagnostics. PeptiDream has an extensive global network of discovery and development partners driving the development and commercialization of a broad and diversified pipeline of investigational therapeutics. PeptiDream also markets and sells a number of radiopharmaceutical and radiodiagnostic products in Japan, through its wholly owned subsidiary, PDRadiopharma.

PRISM BioLab is committed to maximizing the potential of its PepMetics™ Technology, transforming the “undruggable” to “druggable” with the aim of finding cures for the incurable. PRISM BioLab is a biotechnology company with PepMetics Technology, a proprietary drug discovery platform. PepMetics Molecules are designed to mimic α-helix or β-turn peptides using unique, stable scaffolds.

Creation of optimal nucleic acid medicine for disease treatment with proprietary technology PURMX's solution is a drug discovery seed of small RNA nucleic acid drugs that fine-tune many target genes and deliver unprecedented therapeutic effects. PURMX already possesses a large amount of functional RNA screening data, which is being further expanded. The first stage of innovative nucleic acid medicine seeds is MIRX002. MIRX002 is a nucleic acid medicine for malignant pleural mesothelioma. We have completed non-clinical trials and are conducting investigator-initiated clinical trials at Hiroshima University Hospital starting in 2021.

RadioNano Therapeutics, a venture company, was established with the support of Kyoto University Innovation Capital Co. Ltd. for the social implementation of Boron Neutron Capture Therapy (BNCT) using highly hydrophilic boron-containing inorganic nanoparticles developed by Professor Naoki Komatsu of the Graduate School of Human and Environmental Studies, Kyoto University and Professor Minoru Suzuki of the Institute for Composite Nuclear Science, Kyoto University.

RaQualia Pharma - We are an innovative pharmaceutical company leveraging our expertise in drug discovery research and our collaborations with state-of-the-art academic research institutions.

Based on the discovery by our Founder, Professor Shimon Sakaguchi, we are developing stable, functional-induced Tregs that are antigen-specific (S/F-iTregs). Our S/F-iTregs address the limitations of earlier attempts to create therapeutic Tregs and competitive advantages over CAR-Treg approaches.

Rege Nephro is a clinical-stage biotech company developing cell therapy for chronic kidney disease (CKD) and small molecule for autosomal dominant polycystic kidney disease (ADPKD), and founded in 2019. There are 13 million patients with CKD in Japan, of which 340,000 are severe CKD patients forced to undergo artificial dialysis. The healthcare cost of dialysis is $12 billion, 4% of the total healthcare cost of Japan. However, there is still no curative treatment for CKD. Rege Nephro tries to treat patients suffering from CKD with cell therapy using nephron progenitor cells differentiated from iPS cells.

REPROCELL supports nearly the entire workflow of stem cell research and pre-clinical drug development. Our unique portfolio includes access to human tissues (BioServe) and human tissue testing (Biopta), in addition to stem cell culture media, reprogramming technologies, reagents, and iPSC-derived cell types (Stemgent). With our deep knowledge of stem cell biology, bioengineered (3D) tissue models (Alvetex) cell differentiation, and pharmacology, REPROCELL is a recognized leader in cutting-edge tools and services to accelerate regenerative medicine and drug development. The newly formed REPROCELL Medical business unit is developing a suite of reagents and services to meet the growing need for clinical-grade products and services that are appropriate for regenerative medicine. In addition, our labs offer diagnostic services for a variety of tests related to tissue compatibility and other biomarkers. And finally, REPROCELL also offers a GMP iPSC master cell bank manufacturing service. *** REPROCELL went public on the Japan JASDAQ in June 2013. Stemgent, BioServe and Reinnervate became parts of REPROCELL in 2014. Biopta was then acquired in 2015.

RevolKa is a pioneer of next-generation protein engineering. We are committed to the discovery and development of innovative proteins by leveraging our proprietary artificial intelligence-integrated directed protein evolution technology, called aiProtein®. RevolKa is open to research collaboration opportunities with partners and also co-development of our internal assets. About aiProtein® RevolKa innovatively integrated directed protein evolution with the transformative digital technology, artificial intelligence (AI) to create a proprietary powerful protein engineering technology, called aiProtein®. aiProtein® remarkably accelerates directed protein evolution and enables to create unprecedented engineered proteins. This platform is a robust solution for biologics engineering, for example, to address issues in developability and manufacturability of therapeutic antibodies. aiProtein® enables multi-dimensional simultaneous engineering for protein properties, such as efficacy, affinity, physicochemical properties, immunogenicity, species cross-reactivity, and so on.

Ribomic Inc. discovers and develops pharmaceutical compounds using RNA aptamers in Japan. It develops drugs in the areas of pain, heart failure, and other diseases. The company has 25 employees as of March 2023 and is headquartered in Minato, Tokyo.

ROHTO Pharmaceutical Co., Ltd is a multinational company with a history of over 120 years, renowned for its fast-moving consumer goods and OTC drugs. Headquartered in Osaka, Japan, with various domestic and overseas subsidiaries. Although we were initially known for OTC drugs, part of our DNA is to do the unexpected, and for the purpose of people and society’s well-being, we pursue businesses not limited to pharmaceutical operations. Our devotion to meet and exceed customer expectations is the core of Rohto’s business, which has been our main motivator and guidance throughout these years. Recently we announced our comprehensive Management Vision 2030, establishing the core areas we want to strengthen by 2030. With our spirit of "NEVER SAY NEVER" we strive to make every individual and society healthier. To accomplish this, we are seeking people who can support and accelerate the growth of Rohto. The driving force behind Rohto is unquestionably the “people”. A truly diverse workforce is inherently stronger as it is highlighted by people from varying backgrounds with unique experiences, points of view, and knowledge. We believe that this plays an important role in maximizing creativity and accelerating innovation. Our way of working is by embracing the spirit of close cooperation, taking challenges, stir passionate debate and being action oriented. A career at Rohto will help you realize your potential and push yourself to be the better version of you. Are you ready to take part in this journey?

By delivering drugs to patients, we contribute to the creation of a happy society!

Senju Pharmaceutical utilized flexible thinking and a curious mindset to continuously develop new drugs primarily for the global field of ophthalmology. But the true "product" we strive for is happiness - the feeling that can be found with better eyesight.

The purpose of the Shionogi Group's corporate activities is, as expressed in the opening of its Company Policy, to "supply the best possible medicine to protect the health and wellbeing of the patients we serve."​ This eternal and unwavering corporate philosophy is a statement of our vision and value to society. To achieve and live by the Company Policy, we have formulated Action Guidelines, which all Shionogi employees share and embrace as norms for daily activities. Through activities based on the Company Policy and the Action Guidelines, Shionogi will continue to contribute to patients, physicians and other healthcare providers, shareholders and investors, and furthermore to society as a whole.

Solasia Pharma - ‘Sol’ means the Sun and ‘Asia’ the Asian counties in Spanish. We desire to be the Sun brightening the future of various people facing many challenges of cancers in Japan and other Asian countries.

Sosei Heptares is a fully integrated biopharmaceutical company focused on bringing life-changing medicines based on world-class science to patients globally. Our vision is to become one of Japan’s global biopharmaceutical champions. Our global business combines our world-leading GPCR-targeted StaR® technology, structure-based drug design and early development capabilities in the UK with a highly experienced clinical development capability and a commercial operation in Japan. We are leveraging these capabilities to generate and advance a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology and inflammatory diseases. We intend to develop these opportunities for patients in Japan and globally both internally and through our partnerships with global biopharmaceutical companies and emerging technology companies. Sosei Heptares operates from key locations in Tokyo and Osaka (Japan), London and Cambridge (UK) and Seoul (South Korea). “Sosei Heptares” is the corporate brand and trademark of Sosei Group Corporation, which is listed on the Tokyo Stock Exchange (ticker: 4565). Sosei, Heptares, the logo and StaR® are trademarks of Sosei Group companies.

TAGCyx’s scientific team has established its proprietary Xenoligo® technology platform, allowing high functional oligonucletide drug discovery. The Xenoligo® platform utilizes genetic alphabet expansion by unnatural base-pairs to generate customized nucleic acid suited for therapeutic applications.

Taiho Pharmaceutical, a subsidiary of Otsuka Holdings Co., Ltd., is an R&D-driven specialty pharma focusing on the three fields of oncology, allergy and immunology, and urology. Its corporate philosophy takes the form of a pledge: “We strive to improve human health and contribute to a society enriched by smiles.” In the field of oncology in particular, Taiho Pharmaceutical is known as a leading company in Japan for developing innovative medicines for the treatment of cancer, a reputation that is rapidly expanding through their extensive global R&D efforts. In areas other than oncology, as well, the company creates and markets quality products that effectively treat medical conditions and can help improve people's quality of life. Always putting customers first, Taiho Pharmaceutical also aims to offer consumer healthcare products that support people's efforts to lead fulfilling and rewarding lives.

Takara Bio Inc. is committed to improving the human condition through biotechnology. Starting as the biomedical business of Takara Shuzo, a fermentation and beverage company founded in 1925 (now Takara Holdings Company, Inc.), Takara Bio has focused on developing research tools for the life sciences, cell and gene therapy technologies, and nutraceuticals since its launch in 1967. The three business units of TAKARA BIO INC are: • Genetic Engineering Research - manufactures and sells research reagents and scientific instruments used by biotechnology researchers worldwide, as well as contract research services. • Agribio - produces and sells health food products whose functionality have been proven by biotechnology, and conducts a mushroom business based on technologies for large-scale mushroom production. • Gene Medicine - conducts clinical development projects to work toward commercializing cell and gene therapies centered on a highly efficient gene transduction method and a lymphocyte expansion-culture system, both using RetroNectin® reagent.

We strive to transform lives. While the science we advance is constantly evolving, our core purpose is enduring. For more than two centuries, our values have guided us to do what’s right for patients and for society. We know that changing lives requires us to do things differently. We start by listening to and addressing what really matters to patients, the people who love them, and those in the healthcare system who provide care. And that’s what inspires us all to be bold, push boundaries and set new standards that open up greater opportunities. Read our community guidelines: https://takeda.info/communityguidelines

Pharmaceutical company focusing on transdermal DDS technology and pain relief therapeutic field

UMN Pharma Co., Ltd. is a bioventure company established in April 2004. The company name is Unmet Medical Needs (UMN), and the company is currently focusing on developing and manufacturing vaccines to prevent infectious diseases.

We will create immunotherapy using nanotechnology as a new treatment option for intractable cancers and viral infections.Uniting Immunity and Nanotechnology for Fighting Cancer and Infectious Diseases

Developsbiosimilar drugs

At Zeria,our business is based on a set of guiding principles we call the Z・E・R・I・A　Five Corporate Spirits. Zoom in on healthcare Excel in quality at every level Reach out to the world Inspire confidence in management Achieve our potential