List of Small Molecule Pharmaceuticals Companies in Netherlands - 36

2-BBB is developing medicines for the treatment of devastating brain diseases. Our proprietary liposomal G-Technology® facilitates entry to the brain while simultaneously enabling sustained delivery of systemically administered therapeutics. Our technology has been shown to be compatible with approved as well as novel therapeutic entities. We have two clinical programs, one targeting multiple indications of brain cancers and the other neuro-inflammatory diseases.

Ace has been delivering custom pharmaceutical solutions for specific patient needs for over 30 years. With our own registrations, compounded products and cosmetics we provide a solution for pharmacists all over the world. In addition we make clinical trial medication on behalf of our customer.

Adcytherix is a biopharmaceutical company focused on the development of novel antibody drug conjugates (ADC) to treat high unmet need diseases.

Alesta Therapeutics is a pioneering company based in Leiden, Netherlands, dedicated to the development of first-in-class small molecules that target GCN2. Our commitment to advanced, high-quality chemistry has led us to develop a clinical candidate with an extensive pre-GLP toxicology and CMC package.

AM-Pharma BV is a biopharmaceutical company developing recombinant Alkaline Phosphatase for clinical use.

AM–Pharma is a biopharmaceutical company developing proprietary recombinant human Alkaline Phosphatase (AP) therapeutics, which have the potential to transform the treatment prospects for patients with Acute Kidney Injury, Inflammatory Bowel Disease and Hypophosphatasia.

Audion Therapeutics is a private biopharmaceutical company dedicated to the discovery and development of drugs for the treatment of acquired hearing loss. Audion’s headquarters are in Amsterdam, The Netherlands with a presence in the Boston area. Founders are Professor Albert Edge of the MEEI (Harvard Medical School) in Boston, Dr Helmuth van Es, founder of Galapagos, Citryll, Antabio and Effecta Pharma and Rolf Jan Rutten CEO. Investors are Eli Lilly and Inkef Capital and the early clinical development of its lead compound LY3056480 was also funded by a Horizon2020 grant from the EU for a consortium of ENT clinical sites in UK, Germany and Greece.

BIMINI Biotech BV is an innovative biotech start-up that is developing unique compounds for oncology.

Centrient Pharmaceuticals is the global business-to-business leader in sustainable, enzymatic antibiotics, next generation statins and anti-fungals. We produce and sell intermediates and active pharmaceutical ingredients (APIs), as well as our own tablets, capsules and other finished dosage forms (FDFs). We stand proudly at the centre of modern healthcare, as a maker of essential and life-saving medicines. With our commitment to Quality, Reliability and Sustainability at the heart of everything we do, our over 1,800 employees work continuously to meet our customers' needs. We work towards a sustainable future by actively participating in the fight against antimicrobial resistance. Founded 150 years ago as the ‘Nederlandsche Gist- en Spiritusfabriek', our company was known as Gist Brocades and more recently DSM Sinochem Pharmaceuticals. Headquartered in Rotterdam (Netherlands), we have production facilities and sales offices in China, India, the Netherlands, Spain, the United States and Mexico. Centrient Pharmaceuticals is owned by Bain Capital Private Equity, a leading global private investment firm.

Solvias helps innovative companies advance their path to commercialization with CMC analytical solutions powered by deep scientific expertise and a relentless focus on our customers' success. With years of expertise in small molecules, biologics and cell and gene therapies, our talented subject matter experts have the know-how, creativity, and tenacity to solve even the most complex analytical challenges. Solvias offers comprehensive solutions from raw materials to drug products to final release testing as well as API development and manufacturing for small molecules. Customers have a single, trusted analytical partner for their entire development journey. Our five global facilities are strategically placed in biopharmaceutical hubs. We are GMP, GLP and ISO certified and conduct over 100 successful customer audits every year. We take pride in putting science and quality at the heart of everything we do, helping our customers bring better and safer products to market faster.

Aberrant functioning of kinases is known to be an important driver in cancer. Targeting hereof has proven to be extremely successful and has already revolutionized the management of numerous types of cancer. At Crossfire Oncology we approach kinases from three different angles: inhibitors, degraders, and degrader antibody conjugates. This tailored approach allows us to design kinase targeting drugs that aim to maximize the therapeutic benefit for cancer patients.

Flindr Therapeutics B.V. is a precision oncology therapeutics company that is developing first-in-class small molecule inhibitors. The company has secured €20 million in Series A financing to advance its pipeline of precision oncology treatments.

New DNA technologies are rapidly being developed and will have an increasing impact on the world and on people's daily life. Future Genomics Technologies aims to translate academic knowledge and novel technologies into usable applications and provide early and easy access to these applications. Our mission is to help you achieve your goals using cutting edge sequencing and bioinformatics technology.

Hercules Pharmaceuticals, Inc is a fully independent pharmaceutical wholesale distributor accredited and licensed by the National Association of Boards of Pharmacy (NABP) in all 50 states. They serve the full spectrum of pharmaceutical care, including retail, compounding, and specialty pharmacy. Hercules Pharmaceuticals is committed to providing high-quality pharmaceuticals and exceptional customer service to their clients.

InnoCore specializes in the formulation, process development, and manufacturing of long acting and minimally invasive injectable drug delivery products. InnoCore offers a unique and highly tunable polymer platform to control the delivery drug compounds, including small molecules (e.g. peptides and low solubles) and biologics (e.g. proteins and antibodies). Our proprietary polymer platform features a variety of benefits to your API's such as: - solving toxicity challenges - maintaining/increasing stability and structural integrity of sensitive compounds (e.g. by applying low temperature process conditions during manufacturing) - sustained release of of drug molecules from days up to at least 6 months - precise control over particle size (preventing absorption by macrophages and ensuring injectability) - ensuring smooth bioavailability - enabling the use of small needle sizes for patient compliance By merging developmental collaborations and licensing partnerships with our exclusive SynBiosys biodegradable polymer technologies, we generate innovative injectable and implantable drug delivery products. We invite you to navigate through our website and discover how we can enhance the performance of your device and/or drug and add value to your product pipeline.

ISA Pharmaceuticals B.V. is an immunotherapy company developing rationally designed, fully synthetic immunotherapeutics against cancer and persistent viral infections. The Company has built a proprietary immunotherapy platform based on the Synthetic Long Peptide (SLP®) concept and AMPLIVANT®technology. SLP®immunotherapies are designed to fully harness and direct the body’s own defenses towards fighting the disease. In December 2017, ISA Pharmaceuticals closed a clinical immuno-oncology collaboration with Regeneron to advance its SLP®lead compound ISA101, an immunotherapy targeting human papillomavirus type 16 (HPV16)-induced cancer, in combination with cemiplimab (REGN2810, Libtayo®), a PD-1 (programmed cell death protein 1) antibody in development by Regeneron, which was recently approved by the FDA as monotherapy for patients with advanced cutaneous squamous cell carcinoma. ISA develops a diverse SLP®immunotherapy portfolio targeting unmet medical needs in cancer and chronic infections, including tailored therapy for rare diseases. ISA´s most advanced clinical-stage immunotherapeutic is ISA101, an SLP® immunotherapy targeting human papillomavirus (HPV)-induced diseases. It is currently in clinical development in advanced and recurrent cervical cancer, incurable HPV16-postive solid tumors and anal intraepithelial neoplasia (AIN). Clinical proof-of-concept has been established in vulvar intraepithelial neoplasia (VIN), a pre-cancerous disease caused by HPV. The company was founded in 2004 by Aglaia Oncology Fund and is based in Leiden, The Netherlands. For more information, please visit www.isa-pharma.com SLP® and AMPLIVANT® are registered trademarks in Europe.

We are a clinical-stage pharmaceutical company discovering and developing therapies targeting mitochondrial disease. Founded by Professor Jan Smeitink, a world-leader in mitochondrial medicine, we are advancing our proprietary science through a wholly-owned clinical and preclinical small molecule pipeline of potential medicines. Our priority is to rapidly develop our pipeline to deliver transformative medicines for patients living with mitochondrial disease. Our in-house scientists are driving innovative research projects and building a portfolio of promising compounds. We have active discovery programmes underway developing new therapies, biomarkers, diagnostic applications and new read-out technologies in the field of mitochondrial diseases. Our lead pipeline asset, KH176, is a potential first-in-class oral small molecule in phase IIb clinical development to treat a range of mitochondrial diseases. It has been granted Orphan Drug Designation for MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) spectrum disorders and Leigh disease in Europe and for all inherited mitochondrial respiratory chain disorders in the US. We work in collaboration with patient organisations internationally as well as a global clinical and academic network to accelerate the discovery and development of our potential medicines for patients with mitochondrial diseases

Lead Pharma is a clinical-stage pharmaceutical research and development company located in Oss, Netherlands. A spinoff from the Hubrecht Institute and the University Medical Center Utrecht, it focuses on discovering and developing innovative small-molecule therapies for autoimmune diseases and cancer. The company operates from Pivot Park, a biopharmaceutical life sciences campus, equipped with labs for all stages of drug discovery, including medicinal chemistry and pharmacology. The management team includes CEO Frans van den Berg and Chief Scientific Officer Arthur Oubrie, supported by a skilled workforce of 29 employees, many of whom have advanced degrees. Lead Pharma is committed to innovation, with a pipeline of oral therapies designed for efficacy and safety. The company actively pursues partnerships, including a collaboration with Roche to develop treatments for immune-mediated diseases. Lead Pharma has raised $11.86 million in funding and holds 10 patents, emphasizing its focus on advancing science in the pharmaceutical sector.

Mair Therapeutics is a preclinical-stage drug discovery company focused on the discovery and development of a small-molecule ion channel activator to treat Parkinson's disease.

Matisse Pharmaceuticals BV was founded in 2014 in Geleen, the Netherlands. Matisse targets life-threatening inflammation by neutralizing cytotoxic components of the inflammatory system. Its main development program is the development of a medicine to fight sepsis and septic shock, which is currently in clinical phase.

Modra (Modulated Oral Drug Absorption) Pharmaceuticals B.V. is a spin-out from two internationally acclaimed centers of excellence in oncology, the ‘Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)’ and the MC Slotervaart (Slotervaart) in Amsterdam. Modra Pharmaceuticals is a clinical stage company that develops new treatment paradigms by enabling oral bioavailability of existing anticancer drugs, “the iv to oral switch”, to improve cancer therapy and supportive care. Modra Pharmaceuticals has several products in preclinical and clinical development including oral formulations of docetaxel and paclitaxel.

NewAmsterdam Pharma - Founded in 2019, NewAmsterdam Pharma is a clinical-stage company focused on the research and development of transformative therapies for cardio-metabolic diseases. Its mission is to improve patient care in populations where traditional therapies have been unsuccessful or are not tolerated. In April 2020, NewAmsterdam acquired Dezima Pharma from Amgen, including all rights for obicetrapib (TA-8995), a novel, selective, cholesteryl ester transfer protein (CETP) inhibitor. The Company is investigating Obicetrapib as the preferred LDL-c lowering therapy for patients who cannot be treated optimally with current available lipid-lowering therapy or for patients with Atherosclerotic Cardiovascular Disease/Familial Hypercholesterolemia (ASCVD/FH) on maximally tolerated statin therapy. In January 2021, NewAmsterdam completed its Series A funding round of $196M (€160M) which will support the full Phase 3 development of Obicetrapib.

Nordic Pharma is a privately owned, medium-size, fully integrated Pharma company with a history of internal product development and acquisitions. We focus on the development and commercialization of specialty products, which include, but are not limited to, niche hospital and orphan products, to address unmet medical needs. Our expertise relies on the development and sales of our own products, but also on partner products acquired at various stages of development. Today, Nordic Pharma has a range of highly specialized proprietary and in-licensed products in the following therapeutic areas: Rheumatology, Women's Health and Critical Care (Anaesthesia, Haematology, Oncology). We have established deep roots throughout Europe, and more recently, expanded outside of Europe, with the creation of an affiliate in Canada. Our driving force is about innovative and efficient products to fight diseases. We strive to bring solutions to specific unmet medical needs, contributing to improved patient care. Nordic Pharma's values of Commitment, Ambition, Respect, Reliability, Integrity and Agility describe our culture and standards and guide us in our way of working.

At Oncosence we target cancer by developing senescence inducing and senolytic (senescent cell killing) compounds

Orexa is a phase 2 pharmaceutical company that develops and commercializes therapeutics to increase food intake. Its lead compound ORE-001 is a proprietary oral formulation, based on a well known anesthetic. The company has started its first phase 2a study in the Prevention of Post-Operative Ileus. Furthermore it is in preparation for phase 2a studies in Anorexia and Cachexia. With these three indications increased food intake could lead to an improved patient health, a shorter hospital stay and significant cost savings. Orexa was founded in 2016 and is headquartered in Herpen (Oss Region, Noord Brabant), The Netherlands. Attractive risk/reward: • Lower risk, because the active substance is already well known for many decades; • Lean and fast development plan; • Very attractive market potential. Strong patent portfolio: • Broad claims for all local anesthetics to increase food intake after both single and repeated administration; • Well understood mode of action; • Novel mode of delivery, with a proprietary oral formulation. We are looking for partnerships with: ★ an experienced mid or big pharma company with a focus on 505(b)(2) applications for the late stage clinical development and for the marketing in the US & EU markets (and possibly more); ★ a suitable Chinese company with experience in phase 2 & phase 3 clinical trials and an effective sales channel in the majority of the Chinese market; ★ a large scale specialized animal food company or a large veterinary drug company for the veterinary applications. We’d love to hear from you. We’ll get back to you as soon as we can! You can contact us at info@orexa.nl.

PamGene is a functional proteomics Company with a unique 3D array platform to measure the ACTIVITY of Tyrosine and Serine/Threonine kinase. We offer Products (described in our Showcase pages, PamStation-12 ®, Pamchip arrays ® and Reagent kits) and Services (lead optimization, translational/ preclinical research and biomarker discovery). We have developed powerful software tools (BioNavigator) for complex data analysis with which you can interpret results in a biological context. We support clinical trials in the oncology area. Pamgene is advancing research in Oncology as well as other areas (Neurobiology, Immunology, Metabolic disorders, cardiovascular respiratory diseases). Our technology has a wide range of Applications from fundamental and discovery research to clinical development of therapeutic and diagnostic biomarkers. Our patented technology stands out in allowing scientists in industry and academia to measure enzyme activity within a cellular context and fully decorated proteins. The assays have high sensitivity, broad kinome coverage and works for many sample sources. PamGene has a strong science foundation and the number of publications applying our technology continues to rise. PamGene's Customer Service team supports your research with dedication. The PamAcademy offers advanced training, from workflows to data analysis, interpretation and storage. PamGene's PamCloud space allows User-interaction and furthers knowledge exploration. Please visit our web site for further information (https://www.pamgene.com/) and get in touch with us! (https://www.pamgene.com/en/landing.htm)

Pantarhei Bioscience BV (PRB) is a company in The Netherlands with an innovative concept of drug development in Woman’s Health. PRB's wholly owned subsidiary company – Pantarhei Oncology (PRO) (http://www.pantarheioncology.nl) develops innovative treatments for Endocrine Cancer. PRB and PRO have developed a product pipeline based on the proven ability to identify novel medical uses of existing molecules, drugs, hormones, biologicals and combinations thereof in these areas of medicine. The main areas of expertise of PRB are reproductive hormone related treatments such as contraception and menopausal hormone therapy (MHT). The main areas of expertise of PRO are and in oncology breast cancer, prostate cancer and ovarian cancer. The business concept of PRB and PRO is to develop the patented new treatment concepts up to proof-of-concept (PoC) in the human (phase II). Using existing molecules often provides first evidence of safety. The business model is based on solid patent protection, internal project management and external research and development activities. Intellectual property (IP) and data supporting the new treatment concepts are licensed out for completion of clinical development (phase III), regulatory approval and sales and marketing by a licensee/partner.

Pharming Group N.V., a biopharmaceutical company, develops and commercialize protein replacement therapies and precision medicines for the treatment of rare diseases and unmet medical needs in the United States, Europe, and internationally. The company’s lead product is Ruconest, a recombinant human C1 esterase inhibitor that is used for the treatment of acute hereditary angioedema. It also engages in the development of rhC1INH for the treatment of pre-eclampsia, acute kidney injury, and COVID-19; leniolisib, a phosphoinositide 3-kinase delta (PI3K delta) to treat patients with activated PI3K delta syndrome; and alpha-glucosidase therapy for the treatment of pompe and fabry diseases. The company has a development collaboration and license agreement with Novartis; and a strategic collaboration agreement with Orchard Therapeutics plc for research, development, manufacturing, and commercialization of OTL-105, an investigational ex-vivo autologous hematopoietic stem cell gene therapy for the treatment of hereditary angioedema. Pharming Group N.V. is headquartered in Leiden, the Netherlands.

Pleco Therapeutics is a specialty biopharmaceutical company developing novel combination chelating agents to detoxify the cancer microenvironment. Their Plecoid™ therapies positively change the balance of protein expression within the cancer microenvironment, removing the burden of toxic metals.

Salvia BioElectronics is pioneering neuromodulation therapy aiming to transform the migraine treatment landscape. Designed to provide meaningful relief, MySalvia Therapy features an ultra-thin implant that comprehensively targets key nerves involved in migraine. ‍Salvia is driven by the belief that people with chronic migraine deserve the opportunity to reclaim their lives. Founded in 2017 and headquartered in Eindhoven, The Netherlands, Salvia is led by a team of industry veterans with extensive experience in medical devices and neuromodulation. Active in the United States, Europe and Australia, the company is advancing clinical development with the support of leading investors. Salvia is also exploring the potential of its technology for the treatment of cluster headache.

Sapreme’s mission is to develop next-generation macromolecule therapeutics by circumventing endosomal entrapment, thereby enhancing target engagement. The company’s proprietary endosomal escape platform improves the therapeutic window by enabling access to intracellular targets with minimal toxicity. This approach is applied for Sapreme’s internal pipeline and is available for partnering, without limitation to biologic modality or indication. Our solution to endosomal entrapment has the potential to re-open myriad drug development pathways for macromolecule therapeutics lacking efficacy and to explore new targets considered “undruggable” by permeabilizing endo-lysosomal membranes, allowing trapped macromolecules to be released, increasing target engagement without negatively impacting the plasma membrane integrity.

Shandong Biotech is a fully-integrated biopharmaceutical company, specializing in the research & development, manufacturing and commercialization of therapeutic products.

Synexa Life Sciences is a global provider of biomarker and bioanalytical services, specialising in the development, validation, and delivery of a wide range of complex and custom-designed assays. With a team of 150 across five global laboratory locations; Cape Town, London, Berlin, Turku (Finland) and Rockville (Maryland USA), we provide innovative solutions to support our customers to achieve their clinical milestones. Our main areas of expertise include biomarker identification and development, clinical bioanalysis, soluble biomarker analysis (utilising MSD, ELISA, RIA, fluorescence and luminescence-based technologies), cell biology (including flow cytometry and ELISpot) and genomic services to support clinical trials and translational studies. We pride ourselves on our deep scientific expertise and our ability to tackle complex problems, translating them into robust and reliable assays to support clinical trial sample analysis. We partner with our customers to contribute to the furtherment of scientific development and ultimately better management and treatment of human health. Synexa, improving the quality of human health through innovative biomarker and bioanalytical solutions.

Tagworks Pharmaceuticals is a precision oncology company using our proprietary Click-to-Release treatment platform to develop a new standard of care for patients suffering from solid tumors by targeting clinically validated tumor markers that so far have remained out of reach of current therapies. Our lead program, TGW101, is an antibody-drug conjugate (ADC) targeting TAG72, a non-internalizing protein found on the surface of many solid tumor cells. We are developing a pipeline of novel cancer treatments leveraging our Click-to-Release technology in a range of therapeutic modalities, including ADCs and targeted radionuclide therapies. We are headquartered in the Netherlands with operations in the U.S. For more information, visit us at www.tagworkspharma.com.

More specifically, Trajectum Pharma is developing novel mRNA-based products, formulated as lipid nanoparticles for the field of rheumatoid arthritis and other inflammatory diseases. Trajectum Pharma is developing a potentially curative, first in class treatment, for which initial proof-of-concept for the treatment of RA has been established.The initial results in preclinical disease models are extremely promising. The long-term vision of the company is to develop an off-the-shelf vaccine for RA, using the principle of tolerance induction. The company has strong ties with Utrecht University, Department of Immunology and Infectious Diseases, Faculty of Veterinary Medicine (Prof. Femke Broere). There is an ongoing co-operation in the field of mRNA technology and lipid nanoparticle formulations with the Weissman Lab at UPenn (Philadephia, PA) (Prof. Drew Weissman).

Treeway is a clinical-stage biotech company developing therapy for ALS, Alzheimer's Disease and other neurodegenerative diseases. Treeway has been formed by the words tree of life and pathway of a disease, for the founders the symbolic way towards a cure. We foresee that medication, research and care will change dramatically in the coming decades and patients will become an essential part of this process on their pursuit for cures in rare and common diseases. Everyone can make a difference and our slogan "one man can and will find a way, why not be that man?"​ underpins our drive.