List of Therapeutic Companies in Hungary - 5

Avidin Ltd. was established in 2002. Avidin has started its drug discovery programme in 2007 in the field of cancer and infectious diseases. The company in-licensed an anti-cancer compound family interfering lipid vesicle formation and trafficking, a novel way to combat this disease. The company is developing novel approaches for high throughput gene expression analysis and screening technologies for drug discovery. Avidin has started focusing on chemical library synthesis in 2007 for patentable bioactive compounds. Avidin is the local distributor of several products related to different molecular biological methods: BioTrove (Woburn, MA, USA), Bioneer (Daeleon, Korea).

We are one of the leading generic pharmaceutical companies in Central Eastern Europe, our activities incorporate all areas of the pharmaceutical value chain. Egis is a member of Servier, a global pharmaceutical group governed by a Foundation. In the 2022/2023 business year Egis Group generated net sales of EUR 631.7 million. Besides Hungary, we sell our products under Egis’ brand names in 18 countries through our network of subsidiaries and representative offices. Our products (active ingredients, tablets, injections, galenic formulations etc.) are available in 100 countries in total through our network of subsidiaries, representative offices or partners. Our focus lies on treating diseases of the cardiovascular and central nervous systems and we also provide modern treatment solutions in the fields of diabetology, skin and wound care. In 2013, we launched our first biosimilar monoclonal antibody (mAb) product, it was also the first mAb in the European Union. Since then, we launched 3 more biosimilar drugs. As one of the companies in the CEE region committed to innovation, we devote more than EUR 45 million yearly to R&D. Our research and development activities focus on high-quality, value-added branded generic products. In the last 20 years, we have invested more than EUR 770 million in improvements in Hungary: we modernized the complete process of finished product manufacturing and established state-of-the-art R&D centres. In Budapest the development of drugs substances and finished products having significant biological activity in very small doses has become possible and the comprehensive modernization of the traditional technology of active ingredient manufacturing has been completed. Large-scale developments at our site in Körmend: inauguration of a new galenic plant (Sept 2019); the major extension of the packaging plant was completed and capacity to manufacture special medicines - typically oncology products - was established (both 2021 autumn).

Osmotica Pharmaceutical is a fully-integrated pharmaceutical company with demonstrated expertise in developing commercially successful products. As one of the world's leading osmotic drug delivery companies, we leverage our significant resources in R&D and proprietary drug delivery technology to address the growing need of the global patient population. We have the resources and experience to successfully commercialize our products through our subsidiaries, Vertical Pharmaceuticals, LLC and Trigen Laboratories, LLC.

More than a CRO, your creative R&D team™ www.pharmahungary.com Mission of Pharmahungary - providing wide range of innovative and cost-effective preclinical pharmacology R&D services focusing on cardiovascular (infarction, heart failure, stroke, sepsis, arrhythmias, etc) and metabolic diseases (diabetes, dyslipidemia, atherosclerosis, obesity, uremia, etc) with strong scientific support - clinical R&D services focusing on special clinical studies including medical device that need sensitive patient population and thereby strong regulatory & scientific support - to manage internal R&D projects to develop new technologies for outlicensing in the fileds of diagnosis and therapy of cardiovascular and metabolic diseases Why Pharmahungary? - Full service: creative, cost-effective, flexible, high quality - Internationally trained management & staff (MDs, PhDs, clinical pharmacologists, PharmDs, chemists, biologists, medical engineers, MBA quality managers) - Complex platforms of cardiovascular and metabolic disease models, - Custom design models with co-morbidities, including large animals - Strong biochemical and molecular biological background for complex proof-of-concept studies - Scientific support based on international scientific excellence (publications over 380, impact factors over 1 400, citations over 26 000) - Strict confidentiality, IP rights under regulations of the European Union For more information please visit: www.pharmahungary.com.

Solvo Biotechnology provides drug-drug interactions and drug transporter studies and assessment services for medical agencies.