List of RNA Therapies Companies in Netherlands - 4

Hybridize Therapeutics is a spin-off from the Leiden University Medical Center and is a therapeutic company focused on developing kidney-protecting modalities for untreated kidney diseases.

InnoSIGN commercializes OncoSIGNal mRNA-based tests that measure the activity of signal transduction pathways in cancer and immune cells to predict how patients will respond to targeted drugs.

We are ProQR, a biotechnology company dedicated to changing lives by developing RNA therapies for rare genetic diseases. We focus our drug development mainly on a group of blinding disorders affecting the retina, called inherited retinal diseases.

More specifically, Trajectum Pharma is developing novel mRNA-based products, formulated as lipid nanoparticles for the field of rheumatoid arthritis and other inflammatory diseases. Trajectum Pharma is developing a potentially curative, first in class treatment, for which initial proof-of-concept for the treatment of RA has been established.The initial results in preclinical disease models are extremely promising. The long-term vision of the company is to develop an off-the-shelf vaccine for RA, using the principle of tolerance induction. The company has strong ties with Utrecht University, Department of Immunology and Infectious Diseases, Faculty of Veterinary Medicine (Prof. Femke Broere). There is an ongoing co-operation in the field of mRNA technology and lipid nanoparticle formulations with the Weissman Lab at UPenn (Philadephia, PA) (Prof. Drew Weissman).