List of Regenerative Medicine Companies in Ohio - 6

Athersys is a clinical stage biopharmaceutical company with a growing pipeline of highly differentiated, potential best in class therapeutics to treat significant and life-threatening diseases. We are engaged in the discovery and development of innovative new medicines designed to extend and enhance the quality of human life. Through the application of our proprietary technologies, we have established a pipeline of therapeutic product development programs in multiple disease areas. This pipeline includes both stem cell therapy and pharmaceuticals.

One of the few FDA-licensed cord blood centers in the U.S., the Cleveland Cord Blood Center (CCBC) collects, processes, stores and distributes stem-cell rich umbilical cord blood for transplantation in patients with life-threatening disorders.

CollaMedix develops medical devices that are based on collagen. These devices are made using electrocompaction technology. Electrocompacted collagen devices can enhance soft tissue repair and augmentation. One example is CollaFabric®, a load-bearing fabric made from collagen.

Trailhead Biosystems merges developmental biology and cell therapeutics with cutting edge hardware, and computerized experimental design and analysis to perform process-specific parameter optimization for customers seeking to develop cell therapies. Implementing Quality by Design (QbD) principles, cell culture optimization is done by utilizing Design of Experiment (DoE) theory combined with Multivariate Data Analysis (MVDA). This allows Trailhead to generate mathematical models of the biological system, understand the effector-response relationship in cell culture, and provide a systems biology analysis of the differentiation space. DoE-based experimental design and robotic execution greatly reduce the number of experiments and time needed for optimizing a large number of variables simultaneously. You will see that Trailhead Biosystems is novel from its ability to: Have computer-based experimental designs executed for advanced cell culture Gain knowledge into how cell culture affects gene expression in cells Mathematically model the effector/response space so virtual experiments can be performed and enable exploration of cell biology to predict how additives will create desirable cell culture fates Address optimization challenges for cell purity and potency Understand the variance in cell manufacturing methods

We are a US biotech company focused on restoring cell health and resilience, with profound initial indications for the treatment of cancers and rare diseases, the protection of multiple organ injuries, and the effective reversal of aging. We are looking for investors, development partners, or licensees. Interested parties please contact us for further information and discussions.

Viscus Biologics was founded in 2012 to help companies solve complex challenges ranging from ideation to high volume production. We are specialists in natural polymer and extracellular matrix materials, with the ability to develop and manufacture highly-specialized components, devices, and products needed to restore tissue to a healthy, functioning, and durable state. A LIFE SCIENCE PARTNER Whatever biomaterial needs you may have, companies can depend on Viscus Biologics for succesful product realization, quality manufacturing and timely distribution. With over ten years of operating excellence, we are thoroughly experienced with established procedures, policies, and a quality system to support product realization. PROVEN PROCESS The established D4 (Define, Discover, Develop, Deliver) process ensures that components, devices, and products are successfully realized and optimized for high performance. ROBUST SUPPLY CHAIN Our robust and domestic centered supply chain and partner network ensures consistency, cost-containment, availability, and timely delivery of components, devices, and products.