List of Implants Companies in Pennsylvania - 12

Actuated Medical has quickly emerged as a leader in the design and development of medical devices and components. Using proprietary actuation technologies, our innovations address a wide variety of medical challenges ranging from clearing occlusions to easing tissue penetration to enabling MRI assisted procedures. From start to finish, our team designs, develops and manufactures under an ISO-certified quality control system. In addition, we continually seek feedback from domain experts to ensure our products not only solve real problems but also are readily accepted by clinicians. With a proven track record of receiving federal grants to support research and development, the company has built a successful business model that takes medical devices from conception to regulatory approval to market.

Cagent Vascular (Wayne, PA) has developed and commercialized its novel angioplasty balloon with Serration Technology to treat blocked arteries in the leg or Peripheral Artery Disease (PAD) and Chronic Limb Threatening Ischemia (CLTI). The Serranator PTA Serration Balloon Catheter is the first and only angioplasty balloon with serration technology

Innovative spine and medical technology company Camber Spine is dedicated to creating surgeon-designed solutions in MIS and minimally disruptive access for the treatment of complex spinal pathology. Incorporating state-of-the-art manufacturing, 3-D printing, and an acute sensitivity to patient anatomy, we are making quantum leaps in the spinal fusion market. Our patented OLIF system and procedure – with its less complicated, simpler approach to treating complex spinal pathologies – is poised to change the way spine care is delivered. Camber Spine now has 20 products with 510(k) clearances and over 28 active or issued patents, including two award-winning, highly innovative and IP protected device platforms that support faster spinal fusion and recovery: ENZA® (MIS Integrated Interbody) spinal fusion implants; and SPIRA® OA (Open Architecture 3D printed) spinal fusion and orthopedic implants. Our 27,000 sq. ft. state-of-the-art facility just outside Philadelphia features meeting facilities, office spaces, a mechanical test lab with full prototype shop and an expanded double cadaver lab.

Helius Medical Technologies is a leading neurotech company in the medical device field focused on neurologic deficits using non-implantable platform technologies that amplify the brain’s ability to compensate and promotes neuroplasticity, aiming to improve the lives of people dealing with neurologic diseases. The Company’s first commercial product is the Portable Neuromodulation Stimulator (PoNS). PoNS™, short for Portable Neuromodulation Stimulator, is an innovative medical device. It is inclusive of a controller and mouthpiece, that delivers mild stimulation to the surface of the tongue. This stimulation triggers a flow of neural impulses to the brain structures that control balance and gait. PoNS is meant to be used in conjunction with supervised therapeutic activity, referred to as, PoNS Therapy™. Use of the device while engaging in movement and coordination tasks promotes neuromodulation, activating brain pathways to help improve balance and gait. PoNS is authorized in the United States as a short-term treatment of gait deficit due to mild-to-moderate symptoms from multiple sclerosis (“MS”) and is to be used as an adjunct to a supervised therapeutic exercise program in patients 22 years of age and over by prescription only. PoNS is authorized in Canada for three indications: (i) for use as a short-term treatment (14 weeks) of chronic balance deficit due to mild-to-moderate traumatic brain injury (“mmTBI”) and is to be used in conjunction with physical therapy; and (ii) for use as a short-term treatment (14 weeks) of gait deficit due to mild and moderate symptoms from MS and is to be used in conjunction with physical therapy; and (iii) for use as a short-term treatment (14 weeks) of gait deficit due to mild and moderate symptoms from stroke, to be used in conjunction with physical therapy. PoNS is authorized in Australia for short term use by healthcare professionals as an adjunct to a therapeutic exercise program to improve balance and gait.

To make bold and positive change in the biomedical and technology markets. An innovation hub, we relentlessly pursue ideas and inventions that result in superior products, processes, and design. This relentless pursuit drives us every day to bring ideas to market that improve lives and give back to the communities in which we operate.

LyGenesis is a biotechnology company with an organ regeneration technology platform enabling a patient’s lymph nodes to be used as bioreactors to regrow functioning ectopic organs. LyGenesis’ lead preclinical program is focused on liver regeneration for patients with end stage liver disease. Other therapeutic targets for organ regeneration include the thymus, pancreas, and kidney. Privately held, LyGenesis is headquartered in Pittsburgh, Pennsylvania.

Orchestra BioMed biomedical innovation company focused on developing transformative therapeutic products for large unmet clinical needs in procedure-based medicine.

Organoid Therapeutics is developing organoid-based technologies to correct hormone deficiencies in patients and streamline drug discovery and toxicology testing in the lab.

At Pera Labs, we develop digiceuticals and ai-powered solutions for difficult health problems such as fertility. The flagship component of our platform technology for fertility treatments is called SPERMAN, an artificial intelligence based sperm sorter system which provides automated solution for time consuming and labor intensive sperm assessment AND sperm selection procedures. SPERMAN helps fertility clinics perform highly accurate sperm assessment and separation in minutes not days. We take a holistic approach to fertility treatments. Therefore, starting from the assessment of sperm and egg cells all the way to newborn screening, our innovative platform technology can provide more efficient and affordable fertility treatment strategies. We are looking for investors, distribution and implementation partners. Join us for making fertility journey affordable and efficient.

Developing surgical solutions to improve peripheral nerve repair: - Accelerating healing following a nerve injury - Improving nerve function following injury and repair

Swan NeuroTech is a Pittsburgh-based startup developing biodegradable implants for peripheral nerve injuries.

INNOVATIVE BONE GRAFTS BASED ON IMPROVED BIOACTIVE GLASS Synergy has identified an optimal bioactive glass particle with a spherical shape and a biomodal size range that has been shown to significantly improve bone healing. Synergy's BioSphere® particles have been engineered to maximize the bone healing potential of bioactive glass. Synergy Biomedical is a privately-held medical device company focused on bringing biomaterial based products to the orthopedic and spinal surgery markets. Synergy's BIOSPHERE Technology represents an innovative approach to advancing bone graft technology, and improving bone healing and patient outcomes. Synergy Biomedical welcomes inquiries from independent sales distributors with an understanding of orthopaedic and spinal surgery. We are looking for distributors with a proven track record who are willing to grow our bone graft market. Please visit our website for more information: www.synergybiomedical.com