List of Bioinformatics Companies in China - 26

Overview: AccutarBio employs artificial intelligence to revolutionize drug discovery. With capabilities in side chain flexible mode ligand docking, virtual screening, and drug ADME property prediction, Accutar’s platform beats the industry standard in computation-aided drug design. The company’s hybrid based approach, which uses computational drug design followed by wet lab validation, greatly reduces the time and cost necessary for traditional drug discovery efforts. Accutar is committed to building strong partnerships, and collaborates across academia and the pharmaceutical industry to solve interdisciplinary problems. The company was founded in 2015 and has locations in both Shanghai, China and New York, NY. Products & Services: Accutar offers two software packages: Chemi-Net and Orbital. Chemi-Net is a molecular graph convolutional network for accurate drug property prediction. It was recently shown to improve the accuracy of ADME property prediction by a large margin in comparison to the widely-used methods https://arxiv.org/abs/1803.06236. Orbital is a deep neural network based docking platform. The prediction accuracy of protein-ligand complex (holo) from ligand free state (apo) structure is significantly higher than current standards. In addition to these tools, AccutarBio offers services in virtual screening for lead discovery; intelligent-SAR for lead optimization and drug property prediction.

Shanghai APTBIO Biotechnology Co., Ltd. was founded in 2004. Its predecessor was the external service platform of the Proteomics Research and Analysis Center of the Shanghai Institutes for Life Sciences, Chinese Academy of Sciences. Through technical cooperation with domestic and foreign high-level research institutions and the innovative ability of its own R&D team, the company has established an enterprise innovation institute, established a large cohort multi-omics research technology platform, a biological drug early research and preclinical CMC research and analysis platform, a biological drug and medical device registration and approval platform, and AI big data algorithm. It has laid out three business sectors: technology services, biopharmaceuticals, and big health consumer medical CRO services, and has built a life science and big health business map that combines AI big data with mass spectrometry multi-omics technology applications.

The company specializes in the development of genetic testing programs, medical testing reagents and bioinformatics data analysis management software.

NeoX Biotech is a China-based biotechnology company that combines AI with biophysics for the discovery and development of macromolecular drugs to treat cancer.

BioCity was established in December 2017. It is an innovative drug company created by local entrepreneurs who have a deep understanding of the Chinese pharmaceutical market and young returned scientists relying on the world's leading open drug innovation platform. The company is committed to the discovery, development and commercialization of novel or highly differentiated candidates (with no modality limitation) to treat diseases with significant unmet medical needs, particularly cancers and Nephropathy. Through internal research, open innovation platform and collaborations, BioCity has established a pipeline of more than 10 innovative programs including small molecules, monoclonal and bispecific antibodies as well as antibody-drug conjugate (ADCs).

Biomarker Technologies provides high-throughput sequencing and bioinformatics services in areas of genomics, transcriptomics, epigenomics, population genomics, etc. They own all types of third-generation sequencing platformsincluding PacBio Sequel II, Sequel, RSII and Nanopore MinION, GridION and PromethION P48 as well as NGS platforms Illumina, DNBSEQ, etc.

About Burning Rock Burning Rock Biotech Limited (NASDAQ: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of： 1) NGS-based therapy selection testing for late-stage cancer patients, with the leading market share in China and over 273,000 tissue and liquid-based tests completed cumulatively. 2) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage. In July 2018, Burning Rock received the first approval for a tumor NGS kit by the National Medical Products Administration (NMPA), which is a significant milestone in the field of in vitro diagnosis in China. Burning Rock’s laboratory has obtained the technical certification of “High-throughput sequencing laboratory” issued by Guangdong Center for Clinical Laboratory, and the CLIA and CAP laboratory quality system certification. The company continues to be committed to the development of innovative and reliable NGS testing products and promoting the development of precision medicine in oncology. 燃石医学（纳斯达克代码：BNR）成立于2014年，公司使命为“用科学守护生命之光”，专注于为肿瘤精准医疗提供具有临床价值的二代基因测序（NGS）。公司业务及研发方向主要覆盖： 1）基于NGS的肿瘤患病人群检测，累计检测样本超过27万例，在中国拥有领先的市场份额； 2）基于NGS的癌症早检，目前已经进入临床验证阶段。 燃石医学于2018年7月获国家药品监督管理局（NMPA）颁发的中国肿瘤NGS检测试剂盒第一证，在体外诊断领域具有里程碑式意义。位于中国广州的实验室通过广东省临检中心颁发的“高通量测序实验室”技术审核，获得美国CLIA和CAP实验室质量体系资质认证；位于美国加利福尼亚州的实验室也已获得CLIA和CAP实验室质量体系资质认证。公司将继续致力于开发创新可靠的NGS检测产品，推动肿瘤精准医疗领域的发展。

Cure Genetics is an innovative gene therapy company focused on the application and development of viral delivery systems and gene editing systems. In response to the clinical needs of complex genetic diseases and refractory tumors, it has conducted extensive international cooperation and established a breakthrough product pipeline, striving to become a benchmark in the global gene therapy field. The company was founded in 2016 and is located in Suzhou Industrial Park. It brings together core talents from different fields at home and abroad to build a complete differentiated platform around the AAV virus delivery system and CRISPR gene editing system. Possess core independent intellectual property rights and create core competitive barriers. At the same time, the company has established a scientific committee composed of internationally renowned scientists and executives from multinational pharmaceutical companies to lay a solid foundation for technology commercialization.

Elpiscience is a clinical-stage biopharmaceutical company dedicated to developing life-changing immuno-oncology therapies for cancer patients worldwide. The company’s innovative approach is focused on removing immunosuppressive factors in the tumor microenvironment, by targeting the adenosine pathway and myeloid checkpoints. A pipeline of novel molecules has been developed using its proprietary platforms including a powerful Bispecific Macrophage Engager (BiME®) technology that connects and activates macrophages for solid tumor killing without causing cytokine storms.

Founded in 2014, HaploX aims to integrate liquid biopsy technology, gene sequencing, artificial intelligence, big data, and other technologies to improve the management of cancer patients. HaploX's technologies include tools for capturing circulating tumor DNA; extracting and amplifying ultra-low concentrations of DNA from liquid samples; performing tagged sequencing; and managing and analyzing the resulting data. Presently, HaploX's polycentric global distribution include: Shenzhen R & D Headquarter, Third-party Medical Laboratory, GMP Factory, US R & D center and ShangRao International Precision Medical Health Industrial Park. HaploX obtained a certificate of participation from EMQN(The European Molecular Genetics Quality Network) in 2017 and achieved both satisfactory results in two external quality assessment schemes: Lung Cancer(NSCLC)2 and Oncogene panel testing. HaploX possesses the most advanced platforms in the world: Illumina's NextSeqs, HiSeq X Tens, NovaSeq 6000 series and digital PCR. HaploX's throughput is now the second in the world rankings. In December 28th, 2017, HaploX Biotechnology raised $32 million in series A+ round. At the same time, NIVIDA accepted HaploX as a member in Inception program(a program started by NIVIDA in order to support startups that are revolutionizing industries with advances in artificial Intelligence and data science). The firm will continue to develop its sequencing technology, which is capable of detecting circulating tumor DNA for personalized cancer therapy.

Hengsai Bio is a tumor immunotherapy developer that engages in R&D and industrialisation of a new generation dendritic cell tumor vaccines.

HitGen Inc. (SSE: 688222.SH), founded in 2012, is headquartered in Chengdu, China, with subsidiaries in Cambridge, UK and Houston, USA. HitGen is committed to building a world-class innovative biopharmaceutical enterprise and contributing to the better life and health of mankind. Engaged in the discovery and optimization of small molecules and nucleic acid drugs, HitGen dedicates itself to cultivating an internationally leading drug discovery and optimization system centered on four key technology platforms, including DNA-encoded library technology (including DEL design, synthesis and screening, and application expansion), fragment-based drug discovery and structure-based drug design technologies (FBDD/SBDD), synthetic therapeutic oligonucleotide technology (STO), and targeted protein degradation technology (TPD). It provides new molecular entities (NMEs) at different stages of research and development for the pharmaceutical industry, through its diversified business models including research and development services, out-licensing of projects at different R&D stages, and new drug launches in the long term, with an aim to address unmet clinical needs with innovative therapeutic solutions. As a leader in the field of DEL technology, HitGen has been committed to the development, application and improvement of DEL technology since its establishment. HitGen has approximately 20 in-house drug discovery projects at different stages of research and development, among which 4 have obtained IND approvals and entered into clinical trials. HitGen is in collaboration with pharmaceutical, biotech and chemical companies, foundations and research institutes in the Americas, Asia, Europe, Africa, and Oceania. For more information, please call +86-28-85197385, +1-508-840-9646 or visit www.hitgen.com. For business development: bd@hitgen.com

A company focusing on innovative drug research and development for pain treatment.

Jacobio Pharma (1167.HK) is committed to developing and providing new and innovative products and solutions to improve people's health. Our pipeline revolves around novel molecular targets on six major signalling pathways: KRAS, immune checkpoints, tumor metabolism, P53, RB and MYC. We aim for our key projects to be among the top three in the world. Our vision is to become a global leader recognized for our impact in drug R&D together with our partners. Jacobio has R&D centers in Beijing, Shanghai and Boston with our Induced Allosteric Drug Discovery Platform (IADDP) and our iADC Platform.

Founded in 2018, Jianda Biopharmaceuticals (Nanjing) Co., Ltd. is a biopharmaceutical company founded by domestic and foreign vaccine research and development, industrialization and commercialization experts and an elite team in the pharmaceutical industry. Its headquarters is located in the Biopharmaceutical Valley of Nanjing Jiangbei New District. Driven by independent innovative technologies, Jianda Biopharma focuses on the development and industrialization of new human vaccines and biopharmaceutical products such as tumor treatment. Since its establishment, the company has devoted itself to research and development and established a DC-targeted VLP vaccine technology platform and a circular mRNA vaccine technology platform with independent intellectual property rights. A series of innovative products based on platform technologies are in the POC, pilot production and pre-IND stages. In 2021, the company completed its angel round of financing, with Shenzhen Songshan Capital and Dongguan Juying Capital investing 33 million yuan, pushing multiple of the company's products from R&D to pre-IND. The company focuses on the field of life and health, introduces company teams, insists on pioneering and innovation, deploys multiple product pipelines, and strives to bring new vaccines developed to the market to benefit human life and health.

LIDE (Lab for Innovated Diagnosis and Experimental Therapeutics) is a translational medicine service provider with 10 years of delivering innovations in oncology translational research and immuno oncology. Founded in 2011 by overseas returnees Drs. Danyi Wen, Yizhun Zhu, et al, LIDE brings together first-class research and management teams with advanced scientific backgrounds to push the frontier of translational medical research. We operate at the forefront of new technologies and adopt the highest international accreditation standards. LIDE offers traditional CRO services like NGS, CR (conditionally reprogrammed) cell lines and has a collection of more than 1500 patient derived xenograft (PDX) models covering 40+ cancer types, of which 200+ are special drug resistant and/or genetically altered. More importantly, LIDE specializes in using its proprietary MiniPDX and Kcell Assay Kit to offer Functional Diagnosis - an evolved approach to drug r&d that maximizes budget efficiency and minimizes time to validation. LIDE differentiates itself from other CROs by continually conducting self-funded internal research of its immense tumor bio bank, and working with KOLs in the academic space to vigorously promote the development and application of translational medical research in China. We also adopt the highest international operational standards. The company owns AAALAC accredited SPF level Animal Centers, safety level 2 laboratories and world-class, state of the art equipment.

NeoCura is a high-tech enterprise that relies on AI technology to create an RNA technology platform and conduct R&D of innovative drugs. The company has built multi-omics big data acquisition platforms and multiple bioomics databases. It uses AI and bioinformatics technology to conduct in-depth drug target mining and fully automated drug design for innovative RNA technology platform upgrades and drug research. It has established leading R&D centers and production centers in Beijing, Shenzhen, and Guangzhou to support pipelines development, platform upgrades, and clinical demand.

NewDEL Biotech is a biotechnology company based in Shenzhen, China, established in 2021. The company focuses on the research and development of new drugs, with a particular emphasis on innovative drugs designed for tumors. NewDEL Biotech utilizes DNA Encoded Library technology to significantly improve the success rate of drug development.

Nutshell Therapeutics Inc. Inventing small molecule in the realm of drug discovery fostered by protein dynamics. Leveraging our cutting-edge technology based on protein dynamics, Nutshell

Founded in 2005, Porton Pharma Solutions Ltd. is an internationally recognized pharmaceutical contract development and manufacturing organization (CDMO) in enabling our global clients to optimize drug development and manufacturing. We provide customer development and manufacturing services for small molecule, Large molecule and Gene and Cell Therapies from pre-clinical to commercialization. As of June 30, 2023, we have a proven record for the delivery of more than 2600 projects and established cooperation with more than 800 global clients. With our 5000+ skilled employees working across 20+ sites around the globe, Porton is committed to becoming the most open, innovative and reliable pharmaceutical service platform in the world and enabling the public's early access to good medicines. Porton is publicly listed on the Shenzhen Stock Exchange (Ticker: 300363). With over 5000 customer-centric employees, operations and commercial offices across the US, EU and China, Porton Pharma Solutions/J-Star Research provides global pharmaceutical companies with innovative, reliable and end-to-end process R&D and GMP manufacturing services across small molecule APIs, TIDES, biologics and Gene & Cell Therapies. We focus on the customer and have been recognized through awards by industry forums and global pharmaceutical companies for our process innovation, supply chain performance, and compliance with global Quality and EHS standards. We constantly strive for excellence and enable the public's early access to good medicines.

TargetRx is a clinical stage, high-tech pharmaceutical R&D company focused on developing next-generation targeted therapies for cancer patients, particularly those who are resistant or refractory to current treatments. TargetRx has developed a series of cutting-edge and efficient small molecule drug discovery platforms, which combine innovative research and development capabilities for drug design, screening, evaluation and optimization. Since its establishment, TargetRx has been granted over 170 patents from authorities in China, the US, Europe, Japan and other regions. Several potential best-in-class compounds are at different stages of multi-national clinical trials. BD Contact: shujun.mai@tjrbiosciences.com.

Westlake Genetech (Hangzhou) Co., Ltd. is an innovative biotech company, a start-up from scientific research achievements of Westlake University. We focus on the rapid development of first-in-class drugs by integrating the 3H (high throughput, high precision, high dimension) biotechnological data production and deep learning modeling. By building technology-driven gene therapy technology platforms and developing differentiated self-developed gene therapy products, we are committed to mapping the full-process implementation of AI-powered gene therapy. Westlake Genetech adheres to the development strategy of "platform + pipeline" dual-wheel drive, actively invests in R&D innovation that combines technological leadership and industrial feasibility, and promotes the technological and commercial landing of AI technology in the vertical field of biomedicine. Our self-developed AI-powered full-chain gene therapy technology platform has evolved to generate a large number of non-liver-targeted AAV capsids, developed gene editing tools with independent intellectual property rights, explored new targets, and developed safe, efficient, and accessible gene therapy innovative therapies for rare diseases, tumors, and other diseases. With the platform's empowerment, it will effectively expand the scope of gene therapy indications, significantly shorten the pipeline development time, improve the pipeline R&D efficiency, and achieve the optimization of cost reduction and efficiency improvement and technology tool selection. We are rapidly advancing our technological achievements to the field of disease treatment, laying out ex vivo and in vivo gene therapy, developing differentiated gene therapy products, and solving more unmet clinical needs.

Innovent Biologics Co is a biopharmaceutical company that focuses on developing innovative biotechnology solutions in the healthcare and pharmaceuticals industry.

自由能计算，化学结构预测；小分子对接；小分子对接计算或者模拟 计算化学，Python ，分子对接，机器学习，数据模型，人工智能，分子对接软件，Amber 软件，Autodock，Schrodinger, MOE，Gaussian 软件，tensorflow, Git, GitHub. 数据分析和建模"，"化学信息学"，"生物信息学"，"量子化学"，"计算化学软件开发"