List of Artificial Intelligence Companies in Italy - 3

We, at iVis Technologies, are considered as the pioneers and innovative thinkers in corneal eye surgery since 1996, the year we launched CIPTA®, our dedicated software for corneal surgery customization, while the majority of refractive surgeries were executed as standard ablations worldwide. Since then, we also considered low invasiveness treatments and patients' wellbeing as the fundamental driving concepts in our R&D activities and thus we developed cTen™, our exclusive no-touch one-step procedure for refractive and therapeutic corneal surgery as the ultimate alternative to LASIK and patient's safety. Nowadays, we are offering the 4D iVis Suite™. the most advanced corneal surgery platform, which includes a comprehensive refractive products portfolio of medical devices. Our iVis Suite™ gives Surgeons the ultimate capability to execute customized refractive treatments correcting wide range of corneal refractive errors with outstanding clinical results and with the lowest possible invasiveness. iVis' R&D activities, along with our mindset for continuous innovation, are the core of our care. Core is Care. Recently, we have introduced the second generation of Precisio™, the world's most advanced High Resolution Tomographer, able to detect the whole anterior corneal segment, incorporating highly detailed epithelial maps and uniquely using a voice driven full automated exam acquisition, for corneal pathology diagnosis and corneal surgery.

Sibylla is an innovative start-up founded in 2017 as a spin-OFF of the INFN (National Institute of Nuclear Physics) and the Trento and Perugia Universities. Its multidisciplinary team of co-founders has developed a pioneering Early Drug Discovery method that applies to the research and design of new drugs, effective against diseases so far incurable. Drug discovery is an extremely complex problem, therefore requiring innovation. Sibylla is a beautiful example of how innovation can be pushed forward by a multidisciplinary and agile team. Sibylla's approach is based on the possibility of simulating the folding pathway from the amino acid sequence as produced by the cells' ribosomes to the native state. Traditional pharmacological methods investigate the target proteins' interaction sites in their native, biologically active state. Novel methods act at the DNA level. Sibylla follows an alternative approach. We identify small molecules that bind to pockets found in the intermediate folding state. These pockets disappear in the native state, and that is why we may try to drug proteins which have been so far considered undruggable. Sibylla technology is called PPI-FIT (Pharmacological Protein Inactivation by Folding Intermediate Targeting). A molecule found through PPI-FIT would impair the folding of the protein, leading it to degradation. The overall effect is a selective reduction of the expression level of the target protein. The medical areas focused on by Sibylla's research include oncology and antibiotic resistance, although the technology can be applied to any therapeutic area. The company is developing a proprietary pipeline of potential drugs. We can also provide co-development or identifying potential drugs for pharmaceutical companies' specific targets. We recently signed a collaboration agreement with an important Pharma company. Besides the promising results already achieved, Sibylla keeps being engaged in developing proprietary computing technology.

Founded in 1949, Stevanato Group is one of the world's largest providers of integrated containment and delivery solutions for the biopharmaceutical industry. From the beginning, the Group has developed its own glass forming technology to ensure quality of the highest standards. The Group includes a wide range of skills dedicated to serving the biopharmaceutical and diagnostic industry. It offers glass containers with its historic Ompi brand, plastic components for diagnostics and medical devices, contract manufacturing services for drug delivery systems, up to inspection, assembly and packaging machines. The Group also provides analytical services and tests that study the interaction between container and drug and integration into delivery sys-tems, supporting the drug development process. By bringing together several skills under the same entity, Stevanato Group is able to offer unique solutions to companies by reducing the time to market and the overall cost.