List of Antiviral Therapies Companies in Italy - 4

Borea Therapeutics develops next-generation gene therapy vectors using a knowledge-based capsid design platform

Genenta (Nasdaq: GNTA) is a clinical stage immuno-oncology company developing a cell-based platform harnessing the power of hematopoietic stem cells to provide durable and safe treatments for solid tumors. Our platform is not tumor type nor target antigen restricted and provides sustained targeted expression of therapeutic payload(s) inside the tumor micro environment. Genenta’s lead product candidate, Temferon™, precisely targets the delivery of interferon-alpha to the tumor micro-environment, minimizing systemic toxicity while breaking tumor-induced immune tolerance. Our treatments are designed as one-time monotherapies, but with the additional potential, when used in combination, to significantly enhance the efficacy of other approved therapeutics.

Lead Discovery Siena - LDS - is an innovative SME focused on the research for new drugs. LDS offers pharmaceutical services for Industry and Academia and has a diversified pipeline of in licensed and proprietary products for oncology and infections therapeutic areas, including rare diseases. LDS was founded as a spin-off of the University of Siena in 2012 by combining the scientific background and the entrepreneurship of its management to offer specific competences and solutions in drug discovery. LDS capitalizes on the wide scientific expertise in pharmacology and medicinal chemistry to efficiently expedite the discovery and development of small molecule medicines. A number of molecules have been successfully advanced by LDS team as evidenced by publications and patents, and several goals achieved in the course of collaborations which earned us the trust of our customers. LDS actively participates to national and international projects, with a special attention to local synergies at industrial and academic level within the Life Science area. LDS laboratories are located in the Toscana Life Sciences facilities (www.toscanalifesciences.org), a non-profit organization supporting research activities and promoting the creation of innovative companies in Life Sciences.

Ulisse BioMed is a healthcare biotech company operating in diagnostics, theranostics and therapeutics with the mission to develop innovative solutions in these fields. Ulisse BioMed has three proprietary technology platforms capable of generating innovative and competitive products: Sagitta (molecular diagnostics), NanoHybrid (theranostics and diagnostics) and Aptavir (therapeutics). Ulisse BioMed owns a portfolio of intellectual properties made of 8 international patent applications that cover the three technology platforms (3 related to Sagitta, 2 related to NanoHybrid, 1 related to Aptavir and 2 transversal to the three platforms), two of them are granted in Italy and in Europe.