Shasqi is pioneering a novel cancer treatment approach through its proprietary Click Activated Protodrugs Against Cancer (CAPAC®) platform, which utilizes a pre-targeting strategy based on in-vivo click chemistry. This innovative method separates the tumor-targeting binder from the therapeutic payload, allowing for selective binding at the tumor site. The clickable binder attaches to tumor receptors, while the clickable payload—either a radioisotope or an inert cancer drug—remains inactive until it encounters the binder at the tumor. This click chemistry reaction activates the payload, ensuring that the therapeutic agent is delivered precisely where it is needed, thereby maximizing its efficacy while minimizing systemic toxicity.

The CAPAC platform not only enhances the therapeutic window of antibody-drug conjugates (ADCs) and targeted radiopharmaceuticals but also expands the range of potential targets for treatment. By decoupling the targeting mechanism from the payload activation, Shasqi's technology allows for the use of various activators and payloads, including monoclonal antibodies, peptides, and small molecules. This flexibility enables the development of combination therapies and the cycling of different payloads throughout a patient's treatment journey. Shasqi has successfully validated CAPAC in clinical settings, demonstrating its safety and effectiveness in activating protodrugs like SQ3370, which showed promising results in patients with advanced soft tissue sarcoma.

United States

Shasqi is a privately held, clinical stage biopharmaceutical company who is focused on bringing the advances of click chemistry to help people fight their cancer. The Click Activated Protodrugs Against Cancer (CAPAC™) Platform is a therapeutic modality based on click chemistry, which utilizes the biocompatible chemical reaction between an attenuated trans-cyclooctene-modified protodrug and a tetrazine-modified biopolymer. The biopolymer is injected in the desired tumor, which then captures and activates an infused protodrug precisely at the tumor site.

Shasqi

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