Mercaptor Discoveries is pioneering a novel approach to neurology through its proprietary CAPTON™️ technology, which focuses on developing a new class of prodrugs called Captons. These small-molecule drugs are designed to address acute and progressive conditions of the central nervous system (CNS) by utilizing bioactive molecules that remain inactive until they encounter specific pathological conditions in the brain. The Captons are engineered to efficiently cross the blood-brain barrier while minimizing interference with healthy brain tissue. This innovative design allows for targeted therapeutic activity, as the Captons are activated in response to elevated levels of reactive oxygen species (ROS) and redox-active transition metal ions, which are typically present in areas of brain injury or dysfunction.

The Capton approach not only enhances drug delivery to the brain but also aims to mitigate excitotoxicity and inflammation, two critical factors in various CNS disorders, including epilepsy and traumatic brain injury (TBI). By leveraging the unique microenvironment of damaged brain tissue, Captons can provide localized treatment that is proportional to the extent of pathology, thereby reducing potential side effects associated with traditional systemic therapies. This method represents a significant advancement in precision medicine, offering the potential for improved efficacy and safety in treating neurological conditions.

United States

Mercaptor Discoveries is dedicated to reshaping neurology through innovation and compassion. The company specializes in discovering an injury-activated molecule with the potential to mitigate brain damage when used prophylactically and treat many conditions. Mercaptor Discoveries develops treatments for brain injury using molecules and has revealed efficacy and safety data for their lead clinical candidate, MD-004, slated to enter the clinic as an antiepileptic. The company was founded in October 2016 by a team of scientists who discovered small molecules that target brain trauma and neurodegenerative conditions.

Mercaptor Discoveries

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