Seranova Bio leverages its innovative Rapid Exoproteome Antigen Profiling (REAP) technology to explore the role of autoantibodies in health and disease. This platform enables the detection of functional autoantibody reactivities that are crucial for understanding disease outcomes. By focusing on the exoproteome—comprising extracellular and secreted proteins—Seranova can identify impactful autoantibody interactions that were previously difficult to detect at scale. The REAP technology utilizes genetically barcoded yeast to present the human exoproteome, allowing for the testing of thousands of reactivities simultaneously. This approach ensures that the detection of conformational epitopes, which are recognized by the majority of antibodies, is both sensitive and accurate.

In addition to REAP, Seranova Bio employs machine learning through its Seravista platform to analyze the extensive dataset generated from its autoantibody profiling. This technology uncovers latent associations between autoantibodies and clinical outcomes, continuously refining its models with new patient data. By integrating high-quality autoantibody data with rich clinical information, Seranova aims to identify promising therapeutic targets, ultimately driving the development of first-in-class therapeutics. This dual approach not only enhances the understanding of autoantibodies in various diseases but also positions Seranova at the forefront of innovative therapeutic discovery.

United States

Seranova Bio is an early-stage company dedicated to the creation of groundbreaking therapeutics. Our proprietary REAP (rapid extracellular antigen profiling) technology and analytics platform enable the discovery of the functional immune interactions that drive health and disease. We were founded in 2020 by Fred Hutchinson Cancer Center professor and serial academic entrepreneur Aaron Ring. Located in the vibrant biotech hub of South San Francisco, we are proudly supported by leading investors Foresite Capital Management and The Column Group.

Seranova Bio

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