MBC Pharma, Inc. is advancing innovative biopharmaceutical technologies aimed at addressing significant medical challenges in oncology and infectious diseases. One of their key technologies focuses on targeting the bone microenvironment, particularly in the context of cancer-induced bone disease and bone cancer. This proprietary approach utilizes bisphosphonates, which are known for their bone-seeking properties, to deliver therapeutic agents directly to the bone. By linking a chemotherapy agent to a bisphosphonate via a phosphate group, MBC Pharma's method enhances the localized concentration of the drug at tumor sites within the bone, thereby improving efficacy while minimizing systemic toxicity. This strategy is particularly crucial given that traditional chemotherapies often fail to achieve effective concentrations in the bone, where many cancer patients experience metastases.

In addition to their bone-targeting technology, MBC Pharma has developed a platform that leverages vitamin transporters to facilitate drug delivery into cells. This innovative design connects vitamin B6 to therapeutic agents, allowing the intact conjugate to utilize vitamin B6 transporters for cell membrane penetration. Once inside the cell, specific enzymes metabolize the vitamin, releasing the drug. This technology is particularly beneficial for nucleoside analogs, which require phosphorylation to become active. MBC Pharma's approach aims to create vitamin B6-based nucleoside monophosphate prodrugs that can effectively treat pancreatic and other cancers, as well as certain viral diseases, by providing a novel mechanism for drug uptake and delivering activated forms of the drug directly to the target cells.

United States

MBC Pharma, Inc. is a pharmaceutical company discovering and developing novel medicines for the treatment of oncology, bone and infectious diseases. MBC Pharma's patented technologies improve upon the benefit of known drugs by adding tissue targeting and increased cancer cell specificity and uptake.

MBC Pharma

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