Elicera Therapeutics is pioneering innovative cancer therapies through its advanced iTANK technology platform and a portfolio of oncolytic viruses and CAR T-cell treatments. The iTANK platform enhances CAR T-cell therapies by arming them with a pro-inflammatory neutrophil-activating protein (NAP) derived from Helicobacter pylori. This approach addresses two significant challenges in treating solid tumors: the heterogeneous expression of target antigens and the immunosuppressive tumor microenvironment. By inducing a pro-inflammatory environment, iTANK-armed CAR T-cells can activate the patient's own immune response against a broader range of tumor antigens, thereby improving the efficacy of the treatment across various tumor types.

Elicera's product pipeline includes several promising candidates, such as ELC-301 and ELC-401, which target B-cell lymphoma and glioblastoma, respectively. ELC-301 utilizes the iTANK platform to target CD20, providing a new treatment option for patients who have relapsed after standard therapies. Meanwhile, ELC-401 aims to treat glioblastoma by targeting the IL13Ra2 antigen, with preclinical studies demonstrating its potential to overcome the challenges posed by the tumor's immunosuppressive environment. Additionally, Elicera is developing oncolytic viruses like ELC-100 and ELC-201, which are designed to selectively infect and destroy cancer cells while stimulating a systemic immune response. These technologies collectively represent a multifaceted approach to combatting cancer, leveraging both cellular and viral immunotherapies.

Sweden

Elicera Therapeutics is a clinical stage cell and gene therapy company focusing on immunooncology. The company develops CAR T-cells against both solid and liquid tumors based on its proprietary technology platform, iTANK, for a parallell activation of an innate immune response against cancer. Elicera also develops next generation oncolytic viruses with three combined mode-of-actions, applicable for treatment of most cancers.

Elicera Therapeutics

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