Galmed Pharmaceuticals is focused on developing innovative therapeutics for metabolic and inflammatory diseases, leveraging a deep understanding of drug research and development. Their lead investigational drug, Aramchol, is a first-in-class synthetic small molecule designed to target stearoyl-CoA desaturase 1 (SCD1), which plays a crucial role in the synthesis of monounsaturated fatty acids. Aramchol has shown promise in treating nonalcoholic steatohepatitis (NASH) and fibrosis by modulating hepatic lipid metabolism, demonstrating significant improvements in NASH resolution and fibrosis in clinical trials. The drug's mechanism of action includes enhancing the trans-sulfuration pathway, which increases cellular antioxidant levels, thereby preserving cellular health.

Another key therapeutic candidate, Amilo-5MER, is a novel peptide that targets the aggregation of Serum Amyloid A (SAA), a pro-inflammatory protein involved in chronic inflammatory responses. By inhibiting SAA aggregation, Amilo-5MER aims to disrupt the self-amplifying cytokine loop that exacerbates inflammation, making it a potential treatment for conditions like ulcerative colitis. This molecule is being developed in collaboration with the Hebrew University of Jerusalem and is currently undergoing Phase 1 trials to assess its safety and pharmacokinetics. Galmed's commitment to addressing chronic inflammatory diseases is evident in their diverse pipeline, which includes ongoing research into additional indications for both Aramchol and Amilo-5MER.

Israel

Galmed Pharmaceuticals Ltd. is a clinical stage drug development biopharmaceutical company for liver, metabolic and inflammatory diseases. Our lead compound, Aramchol™, a backbone drug candidate for the treatment of NASH and fibrosis is currently in a Phase 3 registrational study. We are also collaborating with the Hebrew University in the development of Amilo-5MER, a 5 amino acid synthetic peptide.
Our corporate headquarters is located in Tel Aviv, Israel. 
For more information about Galmed, please visit our website at: www.galmedpharma.com

Galmed Pharmaceuticals

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