PapiVax Biotech, Inc. is at the forefront of developing innovative immunotherapy solutions targeting human papillomavirus (HPV) infections and associated cancers. The company’s primary technology involves self-adjuvanting DNA vaccines, which are designed to elicit a robust immune response against chronic viral infections. Their lead candidate, PVX-4, is a DNA vaccine that encodes specific HPV16 genes and is administered alongside a heterologous booster immunization. This approach aims to eliminate HPV16-positive cells in patients with high-grade cervical and other related intraepithelial neoplasias, potentially reducing the need for surgical interventions. Early clinical trials have shown promising results, indicating high levels of viral clearance and resolution of abnormal pathology.

In addition to PVX-4, PapiVax is advancing other candidates such as PVX-7 and PVX-8, which target HPV-associated cervical and oropharyngeal cancers. PVX-7 combines DNA vaccines encoding HPV16 and HPV18 genes with a recombinant vaccinia virus vector, while PVX-8 focuses on treating patients with chronic HPV infections linked to low-grade precancerous lesions. Both candidates utilize a heterologous prime-boost immunization strategy to enhance therapeutic efficacy. The company is also leveraging advanced delivery systems, such as the TriGrid Delivery System, to optimize vaccine administration. With a robust pipeline and ongoing clinical trials, PapiVax aims to address significant unmet medical needs in the realm of HPV-related diseases.

Taiwan

PapiVax Biotech, Inc. (PBI) is a biotechnology company that intends to become a global leader in immunotherapy for chronic viral infections and related cancers through application of our state-of-the-art immunology and virology expertise, first to develop safe and effective treatments for human papillomavirus (HPV) infections and related cancers and then to expand application of our immunotherapy platforms against other chronic virus infection-related human cancers.

PapiVax Biotech, Inc.

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