CytoMed Therapeutics is at the forefront of developing innovative cellular immunotherapies aimed at treating a wide spectrum of cancers. The company focuses on "off-the-shelf" solutions utilizing gamma delta (γδ) T cells and natural killer (NK) cells, which are engineered to recognize and eliminate cancer cells effectively. Their proprietary technologies include the iPSC-γδ NKT cell technology (gdNKT therapy) and CAR-γδ T cell technology (CTM-N2D therapy). These approaches leverage induced pluripotent stem cells (iPSCs) to create versatile and potent cellular therapeutics that can be manufactured independently of patient blood cells, thus enhancing accessibility and scalability.

CytoMed's pipeline features several promising therapies, including CTM-N2D and CTM-GDT, both designed for relapsed or refractory solid tumors. These therapies capitalize on the unique antigen recognition capabilities of NK cells and γδ T cells, potentially offering a more robust treatment option compared to traditional autologous cell therapies. By utilizing allogeneic γδ T cells derived from healthy donors, CytoMed aims to overcome limitations associated with patient-derived cells, such as limited availability and quality issues. The company is committed to advancing these technologies through clinical trials, with the goal of providing effective and affordable cancer treatments.

Singapore

Incorporated in 2018, CytoMed was spun off from the Agency for Science, Technology and Research (A*STAR), Singapore’s national research and development agency in the public sector. CytoMed is a biopharmaceutical company focused on harnessing its licensed proprietary technologies to create novel cell-based immunotherapies for the treatment of human cancers. The development of novel technologies has been inspired by the clinical success of existing CAR-T in treating hematological malignancies as well as the current clinical limitations and commercial challenges in extrapolating the CAR-T principle into treatment of solid tumors.

CytoMed Therapeutics

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