Kodiak Sciences Inc. is focused on developing innovative therapies for retinal diseases, leveraging its proprietary Antibody Biopolymer Conjugate Drug (ABCD) Platform. This platform is designed to enhance the durability and efficacy of biologic treatments by combining multiple therapeutic modalities within a single molecule. The ABCD Platform utilizes a bio-inspired polymer that creates a protective environment around the therapeutic antibodies, allowing for high binding affinity and specificity while minimizing non-specific interactions. This design aims to improve the therapeutic concentration levels in the eye, ensuring that treatments remain effective for longer periods, which is particularly crucial for conditions like age-related macular degeneration and diabetic retinopathy.

The company’s pipeline includes several investigational therapies, such as Tarcocimab Tedromer, KSI-501, and KSI-101, each targeting different aspects of retinal diseases. Tarcocimab Tedromer is an anti-VEGF biologic designed for long-interval dosing, while KSI-501 is a bispecific antibody that targets both IL-6 and VEGF, addressing inflammation and vascular permeability simultaneously. KSI-101 is another bispecific protein aimed at treating macular edema associated with inflammation. By focusing on multi-mechanistic approaches, Kodiak aims to tackle the complex pathophysiology of retinal diseases, potentially offering new solutions for patients with limited treatment options.

United States

Kodiak Sciences Inc., a clinical stage biopharmaceutical company, engages in researching, developing, and commercializing therapeutics to treat retinal diseases in the United States and international markets. Its lead product candidate is KSI-301, a vascular endothelial growth factor (VEGF)-biological agent that is in Phase 1b clinical study to treat wet age-related macular degeneration (AMD) and diabetic retinopathy, including diabetic macular edema, as well as for macular edema due to retinal vein occlusion. The company’s preclinical stage product candidate includes KSI-501, a bispecific anti-interleukin 6/VEGF bioconjugate conjugate to treat neovascular retinal diseases with an inflammatory component. Its early research pipeline includes KSI-601, a triplet inhibitor for the treatment of multifactorial retinal diseases, such as dry AMD and the neurodegenerative aspects of glaucoma. The company was formerly known as Oligasis, LLC and changed its name to Kodiak Sciences Inc. in September 2015. Kodiak Sciences Inc. was founded in 2009 and is based in Palo Alto, California.

Endocrine System Diseases

Eye Diseases

Nervous System Diseases

Kodiak Sciences Inc.

Non-proliferative diabetic retinopathy

KSI-301 is an investigational anti-VEGF therapy built on the Kodiak's Antibody Biopolymer Conjugate (ABC) Platform and is designed to maintain potent and effective drug levels in ocular tissues for longer than existing agents. Kodiak's objective with KSI-301 is to develop a new first-line agent to improve outcomes for patients with retinal vascular diseases and to enable earlier treatment and prevention of vision loss for patients with diabetic eye disease.

Tarcocimab (KSI-301) (anti-VEGF)

Eye disease

Wet age-related macular degeneration

KSI-501 is an investigational, first-in-class bispecific ABC that is designed to inhibit two mechanisms implicated in retinal diseases: vascular endothelial growth factor ("VEGF") and interleukin-6 (IL-6). IL-6 is a pro-inflammatory cytokine and growth factor implicated in the pathophysiology of multiple retinal diseases and, in conditions for which anti-VEGF treatment is used, elevated levels of ocular IL-6 have been associated with poor anti-VEGF treatment response. KSI-501 is a trap-antibody fusion biopolymer conjugate designed to provide potent inhibition of (i) VEGF-mediated angiogenesis and vascular permeability through a soluble decoy receptor inhibiting the binding of VEGF-A and PLGF to their cognate receptors and (ii) IL-6 mediated inflammation through an antibody that binds soluble interleukin-6, inhibiting its binding to both soluble and membrane-bound IL-6 receptors. In primary cell assays, KSI-501 inhibits angiogenesis and also normalizes inner and outer blood retinal barriers; dual inhibition of VEGF and IL-6 by KSI-501 confers superior normalization of cell morphology and junctional biology compared to either anti-VEGF or anti-IL-6 monotherapy. We believe KSI-501 has the potential to become a new category of retinal medicines with greater therapeutic efficacy than existing therapies while also benefiting from the promising long-interval durability of Kodiak's ABC Platform. A Phase 1 study of KSI-501 is currently enrolling patients in the United States to evaluate the safety, tolerability and bioactivity of KSI-501 in DME patients.

KSI-501 (anti-VEGF & IL-6)

KSI-101 is&nbsp;the unconjugated protein portion of KSI-501 and is a novel bispecific protein targeting IL-6 and VEGF. We intend to develop KSI-101 for patients who have retinal fluid and inflammation. Currently there are no available intravitreal biologic therapies addressing the spectrum of inflammatory conditions of the retina. We believe that retinal inflammatory conditions represent a new market segment separate from the established anti-VEGF market. KSI-101 is a clinical prospect with opportunities and risks uncoupled from the ABC Platform, and as such is an important part of our late-phase portfolio. We intend to initiate a dose-finding Phase 1b study in the second quarter of 2024 to evaluate its safety and tolerability and identify two dose levels to progress into pivotal studies. We are currently in the process of obtaining regulatory feedback on the design of the pivotal program, and we hope to initiate dual Phase 2b/3 studies later in 2024.

Kodiak Sciences Inc.

Company Details