Aptinyx Inc. is a clinical-stage biopharmaceutical company dedicated to discovering and developing innovative therapies for disorders affecting the brain and nervous system. The company focuses on creating proprietary synthetic small molecules that modulate NMDA receptors, which play a crucial role in normal brain function and synaptic plasticity. This unique approach aims to enhance neural communication rather than simply blocking or over-activating these receptors, potentially leading to transformative treatments for conditions such as post-traumatic stress disorder, cognitive impairment, and opioid use disorder.

The company's development pipeline includes several product candidates currently in clinical trials, with a particular emphasis on NMDA receptor positive allosteric modulators like NYX-783. Recent preclinical data presented at scientific conferences highlight the efficacy of these compounds in addressing stress-induced behavioral changes and their potential application in treating opioid use disorder. Aptinyx's ongoing research and development efforts are expected to yield a diverse array of small-molecule therapies aimed at improving outcomes for patients with various neurological disorders.

United States

Through our drug development expertise in brain & CNS disorders, we have developed a unique medicinal chemistry platform to discover novel product candidates. The compounds we have discovered work through modulation of NMDA receptors to avoid caustic effects associated with over-activation or full inhibition.

Aptinyx Inc. 

Central nervous system illness

Mental health

Parkinson's disease

It is believed that the loss of dopaminergic neurons and the associated downstream changes including dysregulation and dysfunction of NMDA receptors, leads to impairments across multiple cognitive domains. NYX-458 has the potential to treat these cognitive symptoms by modulating NMDA receptor function to overcome the dysregulation caused by the loss of dopaminergic neurons.

NYX-458 

Post-traumatic stress disorder

Psychiatric disorder

NMDA receptors are critically important in normal brain and nervous system function and play a key role in regulating how neurons connect to each other. The activation and opening of NMDA receptors, in response to the binding of specific neurotransmitters including glutamate, triggers a cascade of events that results in synaptic plasticity. This activation may be a beneficial therapeutic approach to treating disorders of the brain and nervous system.

NYX-783 

Diabetic peripheral neuropathy

NYX-2925

Fibromyalgia

NMDA receptors are critically important in normal brain and nervous system function and play a key role in regulating how neurons connect to each other. The activation and opening of NMDA receptors, in response to the binding of specific neurotransmitters including glutamate, triggers a cascade of events that results in synaptic plasticity. This activation may be a beneficial therapeutic approach to treating disorders of the brain and nervous system.

Aptinyx Inc.

Company Details