Holostem Tarapie Avanzate is a biotech company focused on the development and commercialization of Advanced Therapy Medicinal Products (ATMPs) that utilize epithelial stem cells for both cell and gene therapy. The company operates from the Centre for Regenerative Medicine "Stefano Ferrari" at the University of Modena and Reggio Emilia, which is recognized as one of the largest research centers dedicated to epithelial stem cell cultures globally. Holostem's mission is to advance regenerative medicine solutions for patients who lack alternative therapeutic options, emphasizing the importance of epithelial stem cells in treating various conditions.

The company has established a state-of-the-art Good Manufacturing Practice (GMP) facility that spans 2,000 square meters, equipped to meet international standards for cell-based therapies. This facility includes multiple specialized laboratories for research and quality control, as well as advanced equipment for cell culture and analysis. Holostem's research pipeline features several ATMPs at various stages of development, targeting conditions such as Limbal stem cell deficiency and different forms of Epidermolysis Bullosa. The company is committed to developing innovative protocols for cell and gene therapy, supported by a robust foundation of over 150 peer-reviewed scientific publications.

Italy

Holostem Terapie Avanzate is the first biotechnological company entirely devoted to development, manufacture, registration and distribution of Advanced Therapies Medicinal Products (ATMPs)
based on cultures of epithelial stem cells both for cell and gene therapy.

The main aim of Holostem Terapie Avanzate is to promote epithelial stem cell-based Regenerative Medicine for patients with no alternative therapeutic solutions.

Holostem Terapie Avanzate is located into the Centre for Regenerative Medicine "Stefano Ferrari"​ of the University of Modena and Reggio Emilia

Eye Diseases

Genetic Diseases

Skin Diseases

Holostem Tarapie Avanzate

Limbal stem cell deficiency

Holostem Therapy #1 (Stem cells)

Biologics

Cell Therapies

Junctional epidermolysis bullosa

Holostem Therapy #2 (Stem cells w/ LAMB3 vector)

Gene Therapy

Dystrophic epidermolysis bullosa

Holostem Therapy #3 (Stem cells w/ COL7 vector)

Holostem Therapy #4 (Stem cells w/ COL17A1 vector)

Europe - West

Equipment

Lentiviral Vector (LVV)

Regenerative Medicine

Stem Cells

Therapeutic

Holostem Tarapie Avanzate

Company Details