Turn Biotechnologies is pioneering advancements in mRNA medicines aimed at reversing age-related diseases by reprogramming the epigenome, which governs cellular functions and gene activity. Their proprietary Epigenetic Reprogramming of Age (ERA™) platform utilizes carefully formulated mRNA cocktails to rejuvenate specific cells while preserving their identity. This innovative approach contrasts with traditional methods like induced pluripotent stem cells (iPSCs), which erase cellular identity. By controlling the timing and dosage of transcription factors, Turn's ERA™ technology aims to restore youthful functionality to cells, addressing the underlying causes of degenerative conditions rather than merely alleviating symptoms.

The company’s development pipeline includes targeted therapies for various age-associated diseases, such as dermatological conditions, osteoarthritis, immunological challenges, and ocular disorders. For instance, TRN-001 aims to restore skin integrity and treat hair loss, while TRN-002 focuses on reversing cartilage damage in osteoarthritis. Additionally, TRN-010 seeks to enhance CAR-T cell therapy by rejuvenating T cells to improve their efficacy against cancer. Turn Biotechnologies is also exploring the use of their Artificial Niche (AN) technology to maintain the quiescence of stem cells, enhancing their potential for tissue regeneration. Overall, Turn's innovative approaches hold promise for addressing significant unmet medical needs in aging populations.

United States

We are a biotechnology company focused on restoring cells’ youthful vigor to repair damage caused by the aging process. Using a proprietary ERA™ Platform, we develop mRNA medicines that are specially formulated to instruct specific cells in the body to fight disease or repair damaged tissue. We do this by reprogramming the epigenome to restore cell function that people often lose as they age. This approach can be used to revitalize different cells throughout the body – we are researching its applicability across multiple therapeutic areas, including dermatologic conditions, immunology, osteoarthritis and ophthalmology.

Eye Diseases

Nervous System Diseases

Skin Diseases

Turn Biotechnologies

Skin Rejuvenation

TRN-001

Biologics

Gene Therapy

Skin Wound

TRN-006

Hair Rejuvenation

TRN-007

Eyelash Growth

TRN-008

Cartilage Damage

TRN-002

Cellular Exhaustion

TRN-010

Glaucoma

TRN-003

Sarcopenia

TRN-005

Eye disease

TRN-004

Mountain View, California, United States of America

California - North

California

CAR-T Immunotherapy

RNA Therapies

Stem Cells

Therapeutic

Turn Biotechnologies

Company Details