Small Molecules for Neurological Conditions

Modulo Bio focuses on reprogramming the brain's immune system, specifically targeting microglia, which are unique immune cells in the brain that play a crucial role in maintaining and protecting neuronal health. Their technology aims to harness the neuroprotective capabilities of microglia to develop innovative treatments for various neurological conditions. By studying the diverse behaviors of microglia in different contexts, Modulo Bio seeks to identify beneficial microglial actions that can be enhanced or restored to promote brain health. This involves utilizing multiple models of the neuroimmune system to discern meaningful signals and behaviors that can inform therapeutic strategies.

The company's platform integrates advanced techniques in stem cell engineering, neurobiology, multiomics, and machine learning to create a comprehensive approach to understanding and manipulating microglial functions. Modulo Bio generates functional microglia from patient cells at scale, allowing for the comparison of cellular behaviors across different individuals. Their innovative "triculture" model, which includes microglia, astrocytes, and neurons, enables rapid testing of various therapeutic candidates and conditions. By employing machine learning to analyze complex microglial behaviors, Modulo Bio aims to uncover critical biological targets and pathways that can lead to the development of neuroprotective drugs, ultimately contributing to the advancement of precision neurology.

United States

Modulo Bio simulates the neuroimmune system to find medication candidates that target microglia cells. The organization's proprietary neuroimmune system mapping platform is designed to identify potential treatments for neurodegenerative diseases such as ALS and FTD.

Modulo Bio

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