Constructive Bio is at the forefront of biotechnology innovation, focusing on two primary technologies: whole genome writing and engineered translation. Their pioneering approach utilizes a patented strain known as Syn61, which allows for the expansion of the genetic code and the synthesis of programmable biomolecules with high fidelity and specificity. This technology enables the creation of novel biopolymers that incorporate non-canonical building blocks, facilitating advancements in therapeutics, chemicals, and biomaterials. By leveraging engineered translation, Constructive Bio can produce sequence-defined biopolymers at scale, which opens up new possibilities for drug discovery and biomanufacturing.

The company’s capabilities extend to developing phage-resistant strains and enhancing biomanufacturing processes, ensuring reliability and robustness in production. Constructive Bio's platform is designed to synthesize entire recoded genomes, allowing for the exploration of chemical spaces that are not accessible through traditional biological methods. This innovative approach not only aims to redefine the future of medicine but also seeks to transform various industrial applications by creating organisms that can interpret genetic information in fundamentally new ways. Through these advancements, Constructive Bio is setting new standards in the biotechnology landscape.

United Kingdom

With the power to skillfully write meaningful DNA sequences, we embark on a new era where precise control over biology and the manipulation of matter in our environment is possible.

Constructive Biology is a spin out from the laboratory of Prof. Jason Chin at the MRC Laboratory of Molecular Biology in Cambridge. 

Our platform allow us to fundamentally reprogram the genetic code, and make molecules that nature could not make before. We will use our technologies to biosynthesize new classes of enzymes, pharmaceuticals and biomaterials.

If you would like to join our team, get in touch!

The Recodery, Lion Works, Station Road EAST, Whittlesford, Cambridge CB22 4WL, GB

Constructive Bio

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