Synthetic Biology to Create Therapeutic Stem Cells

GC Therapeutics (GCTx) is pioneering advancements in cell therapy through its innovative TFome™ platform, which is the first "plug-and-play" system for programming induced pluripotent stem cells (iPSCs). This technology addresses the complexities and inefficiencies traditionally associated with cell therapy development and manufacturing. By leveraging synthetic biology, gene editing, cell engineering, and machine learning, TFome™ enables the rapid differentiation of iPSCs into various functional cell types. This process is streamlined into a single-step, four-day protocol that achieves over 90% efficiency, significantly reducing the time and cost typically required for cell therapy production. GCTx aims to enhance patient access to advanced therapies by delivering off-the-shelf iPSC-based medicines at a pace up to 100 times faster than conventional methods.

The TFome™ platform is designed to optimize the differentiation of iPSCs by utilizing a comprehensive collection of human transcription factors (TFs) that dictate cell fate through specific signaling pathways. This sophisticated approach allows GCTx to create a diverse pipeline of potential therapies targeting gastrointestinal, neurological, and immunological diseases. By employing advanced multidimensional screening and machine learning techniques, GCTx can identify the most effective TF combinations for cell differentiation, thereby positioning itself as a leader in the iPSC-based cell therapy landscape. The company's commitment to developing first-in-class and best-in-class cell therapy products underscores its mission to revolutionize treatment options and improve patient outcomes across a wide range of medical conditions.

United States

GC Therapeutics Inc. (GCTx) uses synthetic biology to program patient-derived stem cells into any cell type with best-in-class efficiency (up to 10X), speed (up to 100X) and scalability. We dictate cells fates in a single step and have validated cells for many applications. We have also developed SuperCells™ by tailoring cells for specific diseases. 

The core technology of GCTx was conceived, invented and perfected in Professor George Church's lab at Harvard Medical School. We are a group of passionate biologists and tissue engineers whose goal is to bring this breakthrough approach to patients.

GC Therapeutics

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