Nuclein's DASH™ Rapid PCR System is a cutting-edge point-of-care platform designed to deliver rapid, sample-to-answer PCR results in just 15 minutes. This system is engineered for ease of use, requiring only one minute of hands-on time, making it suitable for various clinical environments, including CLIA-waived settings. The DASH™ system utilizes quantitative PCR and reverse transcription real-time PCR (RT-qPCR) methods to detect nucleic acids from a wide range of sample types. It features a compact design, weighing less than 10 pounds, and incorporates an intuitive user interface that guides operators through the testing process, akin to using a coffee maker. The system is capable of multiplex testing, allowing for the simultaneous detection of multiple pathogens, and provides central lab-quality results with a limit of detection of 150 copies per milliliter.

The DASH™ Rapid PCR System has demonstrated impressive clinical performance, achieving 96% sensitivity and 98% specificity in trials, with an overall agreement of 98% compared to established laboratory-based PCR systems. This technology not only facilitates rapid diagnosis of SARS-CoV-2 but also holds potential for broader applications in infectious disease testing. The system's design emphasizes minimal maintenance and the use of stabilized reagents, which can be stored at room temperature, enhancing its accessibility in diverse healthcare settings. Nuclein's commitment to advancing molecular diagnostics is further underscored by its collaborations with universities to improve testing capabilities, particularly in low- and middle-income countries.

United States

Nuclein, LLC was founded in 2017 by experienced biotechnology entrepreneurs Alan Blake and Dr. Richard Crockett. The company's mission is to create a hand-held, disposable, all-in-one, self-test for infectious disease testing, which delivers battery-powered, sample-to-answer results within one hour, without the need to mail in a sample.

The company is headquartered in Austin, Texas.

Nuclein

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