Arima Genomics specializes in advanced 3D genomics technologies that provide comprehensive insights into the sequence, structure, and regulatory landscape of genomes. Their flagship product, the Arima Hi-C technology, utilizes a proximity ligation method to capture the three-dimensional organization of chromatin. This approach allows researchers to identify interactions between genomic loci that may be distant in linear sequence but are close in three-dimensional space. The technology supports a variety of applications, including the study of gene regulation through promoter-enhancer interactions, detection of structural rearrangements, and the construction of high-quality genome assemblies. The Arima Hi-C workflow is designed for efficiency, featuring a rapid six-hour protocol that accommodates various sample types, including low-input and formalin-fixed paraffin-embedded (FFPE) samples.

In addition to Hi-C, Arima Genomics offers a suite of products and services that enhance genomic research. Their offerings include HiChIP for exploring dynamic gene regulatory mechanisms, Custom Capture HiC for targeted genomic regions, and Genome Assembly HiC for constructing reference-quality assemblies. The technology is integrated with user-friendly workflows and robust library preparation protocols, making it accessible for researchers across different fields. Arima Genomics emphasizes the importance of spatial relationships in genome structure, particularly in understanding epigenetics, human health, and cancer genomics, thereby accelerating the discovery of novel biomarkers and therapeutic targets.

United States

Arima-HiC is a proximity ligation method that captures the three-dimensional organizational structure of chromatin, where genomic sequences that are distal to each other in linear distance can be closer to each other in the 3D space. The high-resolution, genome-wide map of interacting genetic loci that is generated from Hi-C data can then be used across multiple genomic applications including identification of promoter-enhancer interactions for gene regulation studies and scaffolding contigs for genome assemblies to define chromosomes de novo.

Arima Genomics

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