Claret Bioscience specializes in advanced technologies for Next Generation Sequencing (NGS) library preparation, particularly focusing on degraded DNA samples. Their flagship product, the SRSLY® Single Reaction Single-stranded DNA Library Prep Kit, is designed to efficiently create complex libraries from minimal input amounts, such as 1 ng of cell-free DNA (cfDNA). This innovative kit allows for the preservation of the native ends of DNA fragments, which is crucial for accurate sequencing and biological interpretation. The SRSLY method is particularly effective for handling challenging samples, including those derived from formalin-fixed paraffin-embedded (FFPE) tissues and ancient DNA, by utilizing a unique approach that denatures DNA before ligation, thus capturing a broader range of DNA types, including damaged and fragmented molecules.

In addition to the SRSLY kit, Claret Bioscience offers the ForShear™ enzymatic fragmentation module, which enhances the quality of genomic DNA extracted from degraded sources. This combination provides an optimized workflow that ensures high-quality sequencing libraries compatible with Illumina® platforms. The technologies developed by Claret Bioscience not only improve the efficiency of library preparation but also enable researchers to extract valuable biological insights from difficult samples, making them a significant player in the field of genomic research and diagnostics.

United States

We are an early-stage biotech startup based in Santa Cruz. We are a small, motivated, multi-disciplinary team innovating in NGS sequencing technologies and DNA assay design for applications in molecular diagnostics with focus on liquid biopsies, FFPE and ancient DNA

Interested in beta testing our single-stranded approach to NGS library prep? Get in touch! www.claretbio.com/contact 

We are always looking to build our team with seasoned scientists who want to be on the ground-level of ground-breaking technology. 

Claret Bioscience

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