Gene Therapy Targeting the Human Commensal Virome

Ring Therapeutics is pioneering a new approach to programmable genetic medicines through its Anellogy™ platform, which leverages the unique properties of anelloviruses, a type of commensal virus found naturally in the human body. This platform aims to create viral-based therapies that can effectively and safely deliver therapeutic payloads to specific cells and tissues. The inherent characteristics of anelloviruses, such as their diversity, ubiquity, and ability to evade the immune system, make them ideal candidates for developing therapies that can target a wide range of tissues while minimizing immune responses. The AnelloVector™ and AnelloLP™ therapeutics are designed to be redosable, allowing for repeated administration without triggering significant immune reactions, which is a common limitation in current viral therapies.

The Anellogy™ platform also emphasizes safety and versatility in gene delivery. Unlike traditional virus-based gene delivery systems that can integrate randomly into the human genome, potentially causing insertional mutagenesis, the AnelloVector™ therapeutics remain as episomes in the nucleus, reducing the risk of disrupting essential genes. This platform is highly modular, allowing for the engineering of various therapeutic modalities and the development of a scalable manufacturing process through the proprietary AnelloBricks™ system. By utilizing the AnelloScope™ discovery engine, Ring Therapeutics is expanding its understanding of anelloviruses and their potential applications, ultimately aiming to transform the landscape of programmable medicine and provide targeted, life-saving therapies for patients.

United States

Powering a new era of gene therapy.

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Ring Therapeutics

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