Gene Tools, LLC specializes in the development and production of Morpholino antisense oligonucleotides, which are designed to bind to complementary RNA sequences and modulate gene expression. These Morpholino oligos are particularly effective in knocking down gene expression, modifying RNA splicing, and inhibiting the activity of microRNAs. Each Morpholino oligo consists of approximately 25 subunits, which include a nucleic acid base, a methylenemorpholine ring, and a non-ionic phosphorodiamidate linkage. Unlike other gene silencing technologies, Morpholinos do not degrade their RNA targets but instead utilize a steric blocking mechanism that is independent of RNAse H activity. This results in a high degree of specificity and stability, making Morpholinos a preferred choice in developmental biology and preclinical drug discovery.

The company also emphasizes the versatility of Morpholinos in various biological systems, including their application in embryos, cultured cells, and adult animals. Gene Tools provides established delivery technologies, such as Endo-Porter for cultured cells and Vivo-Morpholinos for in vivo applications, facilitating the effective introduction of Morpholinos into target cells. The company prides itself on its customer support, offering assistance from Ph.D.-level scientists to help design experiments and troubleshoot issues. With a growing database of over 12,000 publications utilizing Morpholinos, Gene Tools continues to be a leader in the field of gene silencing, providing reliable tools for genetic studies and drug target validation.

United States

Gene Tools, LLC

Oregon

Antisense Oligonucleotides

Gene Tools, LLC

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