Expression Manufacturing leverages advanced technologies in the field of gene therapy, particularly through its proprietary Expression Cassette Optimization (ECO) platform. This innovative system utilizes artificial intelligence, machine learning, and neural networks to enhance the nucleic acid sequences of gene therapy products, ensuring efficient expression in targeted cell types. The ECO platform is designed to optimize transgene performance by tailoring solutions to meet specific client needs, thereby minimizing the iterative design process typically associated with codon optimization. This approach not only improves expression in target tissues but also reduces off-target expression, enhancing the overall safety and efficacy of therapies, including mRNA, AAV, and lentiviral treatments.

In addition to the ECO platform, Expression Manufacturing employs a next-generation lentiviral vector production system that incorporates significant advancements from third-generation lentiviral vector systems. This system is designed to increase titer and safety through the use of custom transgenes flanked by motifs that limit translational readthrough. The company’s Lenti Launch service streamlines the transition from candidate selection to Good Manufacturing Practice (GMP) vector production, allowing for direct synthesis and cloning of customized sequences into the LentET transfer plasmid. This comprehensive approach, combined with their expertise in manufacturing lentiviral vectors, positions Expression Manufacturing as a leader in providing high-quality vector designs and production capabilities for gene therapy applications.

United States

We are a specialty CDMO for LV vector manufacture & use. Our three platforms: Expression Cassette Optimization (ECO), LentET (3rd gen system), & LentET Express (cGMP mfg.) enable GMP LV manufacture 10 months from sequence submittal. ECO increases expression up to 8 fold. LentET plasmids are ECO optimized, have improved safety, produce potent LVs & may be available royalty/licensing free depending upon the specifics. With full CMC & regulatory support, Expression is your preferred CDMO of choice.

Expression Manufacturing

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