X-Therma Inc. is at the forefront of biopreservation technology, focusing on the preservation of living medicines, including organs, engineered tissues, and advanced cell and gene therapies. Their flagship products, XT-Thrive®, XT-ViVo®, and TimeSeal®, utilize innovative, non-toxic cryopreservation media and solutions that eliminate the use of harmful substances like dimethyl sulfoxide (DMSO). XT-Thrive® is a cGMP-grade cryopreservation medium designed for clinical and commercial applications, while XT-ViVo® and TimeSeal® have received FDA Breakthrough Device Designation for their ability to preserve organs for up to five days at subzero temperatures. This technology addresses the critical issue of organ availability, significantly extending the preservation time and improving the logistics of organ transplantation.

The company’s approach is inspired by nature, particularly the antifreeze proteins found in arctic species, which prevent ice crystal formation and cellular damage during preservation. X-Therma has developed a new class of biomimetic molecules called peptoids, which serve as effective cryoprotectants, allowing for safe storage of biological materials at temperatures as low as -196°C. These advancements not only enhance the viability and functionality of preserved cells and tissues but also pave the way for more efficient organ transport and transplantation processes. By removing time constraints from organ preservation, X-Therma aims to revolutionize regenerative medicine and significantly improve patient outcomes.

United States

X-Therma Inc. is solving unmet legacy needs in the storage of biological products using convergent biomimetic nanotechnology. This solution can better enable critical biomanufacture processes, safer transport and long-term biobanking for advanced cell therapies, in vitro fertilization, organ transplants, and other rapidly growing regenerative medicine areas.

X-Therma inc.

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