LineaRx, a subsidiary of Applied DNA Sciences, focuses on revolutionizing the production of therapeutic DNA through its innovative LinearDNA™ platform. This enzymatic DNA manufacturing approach allows for the rapid and scalable production of high-quality DNA, which is essential for various nucleic acid-based therapies, including mRNA, cellular and gene therapies, and DNA vaccines. Unlike traditional plasmid DNA (pDNA) methods that have remained largely unchanged for decades, LineaRx's technology significantly enhances the speed, purity, and flexibility of DNA production. The platform ensures that 100% of the produced DNA consists of the target therapeutic sequence, thereby minimizing impurities and risks associated with conventional methods.

Additionally, LineaRx has developed the Linea™ IVT technology, which combines its enzymatically-produced DNA templates with proprietary RNA polymerase to streamline mRNA production. This next-generation approach reduces or eliminates double-stranded RNA impurities without compromising yield, thus enabling more efficient development of nucleic acid-based therapies. The advantages of the LinearDNA platform over traditional pDNA methods include a faster manufacturing timeframe, the ability to produce long homogenous poly-A tails necessary for mRNA templates, and a significant reduction in the risk of antibiotic resistance and endotoxin contamination. Overall, LineaRx is positioned to meet the growing demand for high-quality DNA in the rapidly evolving field of modern medicine.

United States

LineaRx, an Applied DNA Sciences, Inc. company (NASDAQ: APDN) delivers enzymatically-produced LinearDNAâ¢ as an alternative to current plasmid-based DNA manufacturing processes with advantages of speed, purity and scalability to support the next generation of nucleic acid-based therapies. Manufactured by a proprietary, large-scale polymerase chain reaction (âPCRâ?) based manufacturing platform, LinearDNA allows for the rapid and efficient cell-free production of high-fidelity DNA sequences.

LineaRx - an Applied DNA Sciences company

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