Polyplus specializes in advanced delivery technologies for nucleic acid-based therapies, focusing on transfection reagents and viral vector production. Their product offerings include a range of innovative solutions such as FectoVIR® for AAV and LV production, which enhance the efficiency and cost-effectiveness of viral vector manufacturing. Additionally, Polyplus provides various transfection reagents like jetPEI® and jetOPTIMUS®, designed for high-performance delivery of DNA, RNA, and other oligonucleotides in both in vivo and in vitro applications. Their lipid-based nanoparticles, such as in vivo-jetRNA®, facilitate mRNA delivery, while their cationic lipids from the LipidBrick® Library support the formulation of lipid nanoparticles for mRNA-based vaccines.

In addition to transfection reagents, Polyplus offers comprehensive services including plasmid engineering, manufacturing, and sequencing, which are essential for optimizing the production of proteins and antibodies. Their FectoCHO® expression system is tailored for transient protein production in CHO cells, while their viral vector DOE service aids in process optimization for scale-up. With a commitment to supporting cell and gene therapy advancements, Polyplus integrates scientific expertise with innovative technologies to enhance the efficiency and reliability of nucleic acid delivery, ultimately contributing to the development of breakthrough therapies.

France

Polyplus, part of Sartorius, is a leading upstream solutions provider for advanced biologic and cell and gene therapy production from research to commercial scale.

An innovator in nucleic acid delivery, the legacy portfolio features process-centric transfection reagents, kits, and support services for viral and non-viral delivery. Custom plasmid vector design and plasmid and protein manufacturing was integrated into the offer in 2022 to expand the products and services portfolio to help the industry optimize process economics while meeting strict scientific and regulatory standards.

Polyplus

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