Symple Surgical is a medical device company that focuses on developing innovative therapeutic technologies, particularly through controlled microwave ablation. Their flagship product, the GRIZZLY™ Microwave Ablation System, is designed to perform automated circumferential and focal ablations using a single disposable device. This system utilizes a proprietary microwave antenna paired with a 50W, 18GHz microwave generator, which allows for precise and uniform energy delivery to targeted ablation zones. The technology is particularly aimed at treating Barrett’s Esophagus, a condition that significantly increases the risk of developing esophageal adenocarcinoma (EAC). The GRIZZLY™ system is designed to be user-friendly, providing automated control and feedback to enhance patient safety during minimally invasive procedures.

In addition to the GRIZZLY™ system, Symple Surgical is also developing the DirectAblate Renal Denervation System™, which features an internally integrated microwave antenna and real-time surface temperature monitoring for enhanced safety. This system is engineered to deliver precise microwave energy to sympathetic nerves, with the goal of treating conditions such as resistant hypertension. The technology's advantages over traditional radiofrequency ablation include faster and more uniform heating, as well as reduced dependence on tissue properties. Symple Surgical's commitment to advancing microwave therapy positions it as a key player in the growing field of minimally invasive medicine, with applications extending beyond gastroenterology into areas such as interventional cardiology and nephrology.

United States

Symple Surgical Inc., (SSI) is a developer of novel ablation technologies using controlled Microwave Energy. Symple Surgical innovation is for the treatment of resistant hypertension via renal sympathetic denervation. The DirectAblate Catheter delivers microwave energy to the depth-specific location of the sympathetic nerves while minimizing thermal exposure to non-targeted areas. Offices located in Northern California and Flagstaff, AZ.

Symple Surgical

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