Lightcast is pioneering a flexible platform designed for the precise interrogation of single-cell interactions and functional dynamics at scale. This technology leverages droplet-based microfluidics and optical electrowetting-on-dielectric (oEWOD) techniques, allowing researchers to conduct massively parallel workflows that can perform thousands of operations simultaneously. The platform's unique capabilities enable the analysis of a wide range of cell types and assays, facilitating complex experiments that combine multiple assays into streamlined workflows. This flexibility is crucial for advancing research in various fields, including drug discovery, basic and translational research, and the development of novel therapeutics.

The Lightcast platform supports a variety of applications, such as studying biomolecule secretion, cell-cell interactions, and targeted cell killing. By enabling the analysis of single-cell functional biology, the technology provides insights into cellular heterogeneity, communication, and the mechanisms driving disease progression. This understanding is essential for developing effective therapies, including immunotherapies and regenerative medicine. Additionally, the platform allows for real-time dispensing of live cells into standard well plates, enhancing downstream applications and facilitating deeper functional characterization of cellular responses.

United Kingdom

Lightcast is developing a novel, droplet-based platform that provides a deeper understanding of cellular function. Compared to standard microfluidic methods, the Lightcast platform offers the ability to run a broader range of assays and to precisely control and track the number, occupancy, location, and movement of each droplet. The unprecedented scalability and flexibility of this approach will help advance translational and basic research as well as streamline development workflows for drugs, therapeutics, and applied biologics.

Lightcast

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