Tessara Therapeutics is pioneering advancements in neurology through its innovative RealBrain® technology, which focuses on creating sophisticated 3D human brain models. This platform is designed to enhance neural drug discovery and regenerative medicine by providing accurate and reproducible high-throughput neural models. The RealBrain® models are characterized by their dense and heterogeneous neural networks, compatibility with automation, rapid generation time, and high optical clarity. These models are produced using a chemically defined matrix that closely mimics the biological environment of central nervous system (CNS) tissue, facilitating the differentiation of neural stem cells and the formation of functional neural networks.

In addition to drug discovery, Tessara is exploring the application of RealBrain® micro-tissues for tissue replacement therapies in neurological diseases. The platform includes four advanced models that represent various brain states, including normal tissue and conditions such as Alzheimer's disease and traumatic brain injury. The RealBrain® micro-tissues not only replicate the complexity of in-vivo neural tissue but also demonstrate synaptic maturity and responsiveness to neurotransmitters. By integrating data science with physiological relevance, Tessara aims to improve the predictivity of efficacy and safety studies, ultimately contributing to the development of effective treatments for neurological disorders.

Australia

Tessara Therapeutics Pty Ltd is a regenerative medicine company developing RealBrain® technology to break therapeutic barriers in the biopharmaceutical industry. RealBrain® technology is based on human mimetic 3D neural micro-tissues designed to have high physiological relevance, manufactured at industrial scale for unprecedented reproducibility. Priority applications include a high-throughput drug screening platform that includes a range of models of healthy and diseased brain tissue, and a regenerative medicine platform to develop next generation safe and efficacious tissue therapies for significant unmet neurological medical needs.

Tessara Therapeutics

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